業 績

Publication list 2024(R6)
1. Koga Ke, Kobayashi K, Tsuda M, Pickering AE, Furue H.
Anterior cingulate cross-hemispheric inhibition via the claustrum resolves painful sensory
conflict.Commun Biol. 2024 Mar 15;7(1):330. doi: 10.1038/s42003-024-06008-9.
PMID: 38491200; PMCID: PMC10943010.[PubMed]

2.Yamada A, Yamada A, Ling J, Furue H, Gu JG.
Effects of inflammation on the properties of Nav1.8-ChR2-positive and Nav1.8-ChR2-negative afferent mechanoreceptors in the hindpaw glabrous skin of mice. Mol Pain. 2024 Jan-Dec;20:17448069241240452. doi: 10.1177/17448069241240452. PMID: 38438192; PMCID:PMC10960352.[PubMed]

3.Yamada A, J Ling, Yamada AI,Furue H, JG Gu.
ASICs mediate fast excitatory synaptic transmission for tactile discrimination. Neuron. 2024 Feb 6:S0896-6273(24)00044-8. doi: 10.1016/j.neuron.2024.01.018.[PubMed]

Publication list 2023(R5)
1. Fujiwara Y, Koga Ke, Nakamura N, Maruo K, Tachibana T, Furue H.
Optogenetic inhibition of spinal inhibitory neurons facilitates mechanical responses of spinal wide dynamic range neurons and causes mechanical hypersensitivity. Neuropharmacology. 2024 Jan 1;242:109763. doi: 10.1016/j.neuropharm.2023.109763.
Epub 2023 Oct 16. PMID: 37852319.[PubMed]

2. Koga Ke, Kobayashi K, Tsuda M, Kubota K, Kitano Y, Furue H.
Voltage-gated calcium channel subunit α2δ-1 in spinal dorsal horn neurons contributes to aberrant excitatory synaptic transmission and mechanical hypersensitivity after peripheral nerve injury.Front Mol Neurosci. 2023 Mar 23;16:1099925.
doi: 10.3389/fnmol.2023.1099925. [PubMed]

3. Nakamura N, Furue H, Kobayashi K, and Oku Y.
Hippocampal ensemble dynamics and memory performance are modulated by respiration during encoding. Nature Communications. 2023 Jul 27;14(1):4391. doi: 10.1038/s41467-023-40139-7.[PubMed]

4. Yamada A, Yamada A I, Jennifer Ling, Furue H, Wenqin Luo Jianguo G. Gu.
Properties of Nav1.8ChR2-positive and Nav1.8ChR2-negative afferent mechanoreceptors in the hindpaw glabrous skin of mice. Molecular Brain (2023) 16:27 https://doi.org/10.1186/s13041-023-01015-z [PubMed]

5. Ueda Y, Uta D, Furue H, Ohtubo Y.
An electrophysiological method for evaluation of topical antipruritic drugs on itch-related neuronal activities in the spinal cord in hairless mice. Eur J Pharmacol. 2023 Aug 5;952:175798. doi:10.1016/j.ejphar.2023.175798. [PubMed]

6. Tanaka T, Okuda H, Isonishi A, Terada Y, Kitabatake M, Shinjo T, Nishimura K, Takemura S, Furue H, Ito T, Tatsumi K, Wanaka A.
Dermal macrophages set pain sensitivity by modulating the amount of tissue NGF through an SNX25-Nrf2 pathway. Nat Immunol. 2023 Mar;24(3):439-451.
doi: 10.1038/s41590-022-01418-5. [PubMed]

7. Kawabata R, Shimoyama S, Ueno S, Yao I, Arata A, Koga Ko.
TRPA1 as a O2 sensor detects microenvironmental hypoxia in the mice anterior cingulate cortex. Sci Rep. 2023 Feb 20;13(1):2960.
doi: 10.1038/s41598-023-29140-8.[PubMed]

8. Kawabata R, Yamanaka H, Kobayashi K, Oke Y, Fujita A, Oku Y, Yao I and Koga Ko. The anterior cingulate cortex is critical for acute stress-induced hypersensitivity in mice. Neuroscience. 2023 Jul 15;523:47-60. doi: 10.1016/j.neuroscience.2023.05.010.
Publication list 2022(R4)
1. Yamada A, Furue H, Gu JG.
Angular Tuning Properties of Low Threshold Mechanoreceptors in Isolated Rat Whisker Hair Follicles. eNeuro. 2022;9(6):ENEURO.0175-22.2022.
doi: 10.1523/ENEURO.0175-22.2022.

2. Tanioku T, Nishibata M, Tokinaga Y, Konno K, Watanabe M, Hemmi H, Fukuda-Ohta Y, Kaisho T, Furue H, Kawamata T.
Tmem45b is essential for inflammation- and tissue injury-induced mechanical pain hypersensitivity. Proc Natl Acad Sci USA. 2022; 119(45): e2121989119. doi10.1073/pnas.2121989119. [PubMed]

3. Nakajima N, Ohnishi Y, Yamamoto M, Setoyama D, Imai H, Takenaka T, Matsumoto M, Hosomi K, Saitoh Y,Furue H, Kishima H.
Excess intracellular ATP causes neuropathic pain following spinal cord injury. Cell Mol Life Sci. 2022 Aug 16;79(9):483. doi: 10.1007/s00018-022-04510-z.[PubMed]

4. Kurabe M, Sasaki M, Furutani K, Furue H, Kamiya Y, Baba H.
Structural and functional properties of spinal dorsal horn neurons after peripheral nerve injury change overtime via astrocyte activation. iScience. 2022 Nov 11;25(12):105555. doi: 10.1016/j.isci.2022.105555.[PubMed]

5. Ishibashi T, Sueto D, Yoshikawa Y, Koga Ke, Yamaura K, Tsuda M.
Identification of Spinal Inhibitory Interneurons Required for Attenuating Effect of Duloxetine on Neuropathic Allodynia-like Signs in Rats. Cells. 2022; 11(24): 4051.
doi: 10.3390/cells11244051[PubMed]

6. Uchiyama S, Yoshihara K, Kawanabe R, Hatada I, Koga Ke, Tsuda M.
Stress-induced antinociception to noxious heat requires α1A-adrenaline receptors of spinal inhibitory neurons in mice. Mol Brain. 2022 Jan 3;15(1):6.
doi: 10.1186/s13041-021-00895-3.[PubMed]

7. Kanehisa K, Koga Ke, Maejima S, Shiraishi Y, Asai K, Shiratori-Hayashi M, Mei-Fang Xiao, Sakamoto H, Paul F Worley, Tsuda M.
Neuronal pentraxin 2 is required for facilitating excitatory synaptic inputs onto spinal neurons involved in pruriceptive transmission in a model of chronic itch. Nat Commun. 2022 May 2;13(1):2367. doi: 10.1038/s41467-022-30089-x.[PubMed]

8. Tozaki-Saitoh H, Koga Ke, Yamaura K, Tsuda M.
Selective Involvement of a Subset of Spinal Dorsal Horn Neurons Operated by a Prodynorphin Promoter in Aβ Fiber-Mediated Neuropathic Allodynia-Like Behavioral Responses in Rats. Front Mol Neurosci. 2022 Jun 23;15:911122.
doi: 10.3389/fnmol.2022.911122.[PubMed]

9. 關巖, 中村亜由美, 古賀啓祐, 青野浩之, 古江秀昌.
マウス青斑核ニューロン活動に対するアセトアミノフェンの効果.PAIN RESEARCH:37巻1号16-25.2022

10. 古江秀昌 中村善隆 中村亜由美 古賀啓祐
脊髄副交感節前ニューロンからのin vivo 電気生理学的記録法. 日本自律神経学会雑誌59巻3号(in press)
Publication list 2021 (R3)
1.Matsumoto Y, Fujino Y, Furue H.
Anesthesia and surgery induce a functional decrease in excitatory synaptic transmission in prefrontal cortex neurons, and intraoperative administration of dexmedetomidine does not elicit the synaptic dysfunction. Biochem Biophys Res Commun. 2021 Jul 28;572:27-34. doi:10.1016/j.bbrc.2021.07.065. Epub ahead of print. [PubMed]

2. Kawai M, Imaizumi K, Ishikawa M, Shibata S, Shinozaki M, Shibata T, Hashimoto S, Kitagawa T, Ago K, Kajikawa K, Shibata R, Kamata Y, Ushiba J, Koga Ke, Furue H, Matsumoto M, Nakamura M, Nagoshi N, Okano H.
Long-term selective stimulation of transplanted neural stem/progenitor cells for spinal cord injury improves locomotor function.Cell Rep. 2021 Nov 23;37(8):110019.
doi:10.1016/j.celrep.2021.110019. [PubMed]

3. Tashima R, Koga Ke, Yoshikawa Y, Sekine M, Watanabe M, Tozaki-Saitoh H, Furue H, Yasaka T, Tsuda M.
A subset of spinal dorsal horn interneurons crucial for gating touch-evoked pain-like behavior. Proc Natl Acad Sci U S A. 2021 Jan 19;118(3):e2021220118.
doi: 10.1073/pnas.2021220118. [PubMed]

4. Shiraishi Y, Koga Kei, Yamagata R, Hatada I, Shiratori-Hayashi M, Tsuda M.
α 1A-adrenaline receptors in dorsal horn inhibitory neurons have an inhibitory role in the regulation of chloroquine-induced itch in mice. Mol Brain. 2021 Mar 16;14(1):55.
doi: 10.1186/s13041-021-00768-9.[PubMed]

5. Kawakami K, Koga Ko.
Acute elevated platform triggers stress induced hyperalgesia and alters glutamatergic transmission in the adult mice anterior cingulate cortex.IBRO Neurosci Rep. 2021 Feb 3;10:1-7.
doi:10.1016/j.ibneur.2020.12.002. [PubMed]

6. Tashima R, Koga Kei, Yoshikawa Y, Sekine M, Watanabe M, Tozaki-Saitoh H, Furue H, Yasaka T, Tsuda M.
A subset of spinal dorsal horn interneurons crucial forgating touch-evoked pain-like behavior. Proc Natl Acad Sci U S A. 2021 Jan19;118(3):e2021220118.
doi: 10.1073/pnas.2021220118.[PubMed]

7. Uta D, Koga Ko, Furue H, Imoto K, Yoshimura M.
L-bupivacaine Inhibition of Nociceptive Transmission in Rat Peripheral and Dorsal Horn Neurons. Anesthesiology. 2021 Jan 1;134(1):88-102.
doi: 10.1097/ALN.0000000000003596.[PubMed]

8. Toyoda H, Koga Ko.
Nicotine Exposure during Adolescence Leads to Changes of Synaptic Plasticity and Intrinsic Excitability of Mice Insular Pyramidal Cells at Later Life. Int J Mol Sci. 2021 Dec 21;23(1):34. doi: 10.3390/ijms23010034.[PubMed]
Publication list 2020 (R2)
1. Matsumoto Y, Fujino Y, Furue H.
Anti-nociceptive and anxiolytic effects of systemic flupirtine and its direct inhibitory actions on in vivo neuronal mechanical sensory responses in the adult rat anterior cingulate cortex. Biochem Biophys Res Commun. 2020 Oct 22;531(4):528-534. doi:10.1016/j.bbrc.2020.07.129. [PubMed]

2. Lee JY, Lee GJ, Nakamura A, Lee PR, Kim Y, Won CH, Furue H, Oh SB.
Involvement of cannabinoid type 1 receptor in fasting-induced analgesia. MolPain. 2020 Jan-Dec;16:1–10. doi: 10.1177/1744806920969476. [PubMed]

3. Koga Ko, Yamada A, Song Q, Li XH, Chen QY, Liu RH, Ge J, Zhan C, Furue H, Zhuo M, Chen T.
Ascending noradrenergic excitation from the locus coeruleus to the anterior
cingulate cortex. Mol Brain. 2020 Mar 26;13(1):49. doi: 10.1186/s13041-020-00586-5.

Publication list 2019(R1)
1. Nakagawa T, Akimoto N, Hakozaki A, Noma T, Nakamura A,Hayashi Y, Sasaki E,
Ozaki N, Furue H.
Responsiveness of lumbosacral superficial dorsal horn neurons during the voiding reflex and functional loss of spinal urethral-responsive neurons in streptozotocin-induced diabetic rats.Neurourol Urodyn. 2020 Jan;39(1):144-157. doi: 10.1002/nau.24198.[PubMed]

2. Nakamori H, Naitou K, Horii Y, Shimaoka H, Horii K, Sakai H, Yamada A, Furue H,
Shiina T, Shimizu Y.
Roles of the noradrenergic nucleus locus coeruleus and dopaminergic nucleus A11 region as supraspinal defecation centers in rats. Am J Physiol Gastrointest Liver Physiol. 2019 Aug 28. doi:10.1152/ajpgi.00062.2019. [Epub ahead of print]

3. Koga Ko, Matsuzaki Y, Migita K, Shimoyama S, Eto F, Nakagawa T, Matsumoto T, Terada K, Mishima K, Furue H, Honda K.
Stimulating muscarinic M1 receptors in the anterior cingulate cortex reducesmechanical hypersensitivity via GABAergic transmission in nerve injury rats. Brain Res. 2019 Feb 1;1704:187-195. doi:10.1016/j.brainres.2018.10.013. [PubMed]

4. 古江 秀昌, 野口光一(担当:共著)
「疼痛医学」教科書制作研究会. 2020年
Publication list 2018(H30)
1. Yamada A, Koga Ko, Kume K, Ohsawa M, Furue H.
Ethanol-induced enhancement of inhibitory synaptic transmission in the rat spinal substantia gelatinosa. Mol Pain. 2018 Jan-Dec;14:1744806918817969. doi: 10.1177/1744806918817969. [PubMed]

2. Qiu S, Wu Y, Lv X, Li X, Zhuo M, Koga Ko.
Reduced synaptic function of Kainate
receptors in the insular cortex of Fmr1 Knock-out mice. Mol Brain 11(1):54, 2018 Sep 21
doi: 10.1186/s13041-018-0396-1. [PubMed]

3. Chen T, Taniguchi W, Chen QY, Tozaki-Saitoh H, Song Q, Liu RH, Koga Ko, Matsuda
T, Kaito-Sugimura Y, Wang J, Li ZH, Lu YC, Inoue K, Tsuda M, Li YQ, Nakatsuka T,
Zhuo M.
Top-down descending facilitation of spinal sensory excitatory transmission from the anterior cingulate cortex. Nat Commun 14;9(1):1886. 2018 May
doi: 10.1038/s41467-018-04309-2. [PubMed]

4. Tashima R, Koga Ko, Sekine M, Kanehisa K, Kohro Y, Tominaga K,
Matsushita K, Tozaki-Saitoh H, Fukazawa Y, Inoue K, Yawo H, Furue H, Tsuda M.
Optogenetic Activation of Non-Nociceptive Aβ Fibers Induces Neuropathic Pain-Like
Sensory and Emotional Behaviors after Nerve Injury in Rats. eNeuro 15;5(1). pii: ENEURO.0450-17.2018 Feb
doi:10.1523/ENEURO.0450-17.2018. eCollection 2018 Jan-Feb. [PubMed]

5. Koga Ko, Shimoyama S, Yamada A, Furukawa T, Nikaido Y, Furue H, Nakamura K, Ueno S.
Chronic inflammatory pain induced GABAergic synaptic plasticity in the adult mouse anterior cingulate cortex. Mol Pain 14:1744806918783478. 2018 Jan-Dec
doi: 10.1177/1744806918783478.[PubMed]

6. 古江秀昌
兵庫医科大学医学会雑誌 43(1) 29‐33 - 33 2018年9月25日
Publication list 2017(H29)
1.Kawatani M, Akimoto N, Yamada A, Furue H, Kawatani M.
Noradrenergic effects in rat sacral autonomic nucleus using in vitro slice patch-clamp recordings. Biomed Res 38(6):359-369. 2017
doi: 10.2220/biomedres.38.359. [PubMed]

2. Nakamori H, Naitou K, Horii Y, Shimaoka H, Horii K, Sakai H, Yamada A, Furue H, Shiina T, Shimizu Y.
Medullary raphe nuclei activate the lumbosacral defecation center through the descending serotonergic pathway to regulate colorectal motility in rats. Am J Physiol Gastrointest Liver Physiol 1;314(3):G341-G348. 2018 Mar
doi: 10.1152/ajpgi.00317.2017. [PubMed]

3. Pham VM, Tu NH, Katano T, Matsumura S, Saito A, Yamada A, Furue H, Ito S.
Impaired peripheral nerve regeneration in type-2 diabetic mouse model. Eur J Neurosci 47(2):126-139. 2018 Jan
doi: 10.1111/ejn.13771.[PubMed]

4. Koga K, Kanehisa K, Kohro Y, Shiratori-Hayashi M, Tozaki-Saitoh H, Inoue K, Furue H, Tsuda M.
Chemogenetic silencing of GABAergic dorsal horn interneurons induces morphine-resistant spontaneous nocifensive behaviours. Sci Rep 5;7(1):4739.2017 Jul doi:10.1038/s41598-017-04972-3.[PubMed]

5. Kurabe M, Furue H, Kohno T.
Corrigendum: Intravenous administration oflidocaine directly acts on spinal dorsal horn and produces analgesic effect: Anin vivo patch-clamp analysis. Sci Rep 1;7:46814. 2017 Jun
doi:10.1038/srep46814. [PubMed]

6.Erami E, Azhdari-Zarmehri H, Imoto K, Furue H.
Characterization of NociceptiveBehaviors Induced by Formalin in the Glabrous and Hairy Skin of Rats. Basic Clin Neurosci 8(1):37-42. 2017 Jan
doi: 10.15412/J.BCN.03080105. [PubMed]

7.Jang IJ, Davies AJ, Akimoto N, Back SK, Lee PR, Na HS, Furue H, Jung SJ, KimYH,
Oh SB.
Acute inflammation reveals GABA(A) receptor-mediated nociception inmouse dorsal root ganglion neurons via PGE(2) receptor 4 signaling. Physiol Rep. 2017 Apr;5(8).
pii: e13178. doi: 10.14814/phy2.13178. [PubMed]

8.Yoshimura M, Furue H.
In vivo electrophysiological analysis of mechanisms ofmonoaminergic pain inhibitory systems. Pain. 2017 Apr;158 Suppl 1:S85-S91.
doi:10.1097/j.pain.0000000000000844. [PubMed]

9.Takayama Y, Furue H, Tominaga M.
4-isopropylcyclohexanol has potentialanalgesic effects through the inhibition of anoctamin 1, TRPV1 and TRPA1 channel activities. Sci Rep. 2017 Feb 22;7:43132.
doi: 10.1038/srep43132. [PubMed]

10.Choi S, Yamada A,Kim W, Kim SK, Furue H.
Noradrenergic inhibition of spinalhyperexcitation elicited by cutaneous cold stimuli in rats withoxaliplatin-induced allodynia: electrophysiological and behavioral assessments. JPhysiol Sci 67(3):431-438. 2017 May
doi: 10.1007/s12576-016-0505-9. [PubMed]

11. Koga K, Yao I, Setou M, Zhuo M.
SCRAPPER Selectively Contributes to Spontaneous Release and Presynaptic Long-Term Potentiation in the Anterior Cingulate Cortex. J Neurosci 37(14):3887-3895.2017 Apr 5 doi:10.1523/JNEUROSCI.0023-16.[PubMed]

12. Koga K, Matsuzaki Y, Honda K, Eto F, Furukawa T, Migita K, Irie K, Mishima K, Ueno S. Activations of muscarinic M(1) receptors in the anterior cingulate cortex contribute to the antinociceptive effect via GABAergic transmission. Mol Pain. 2017 Jan;13:1744806917692330.
doi: 10.1177/1744806917692330.[PubMed]

13. Tsuda M, Koga K, Chen T, Zhuo M.
Neuronal and microglial mechanisms for neuropathic pain in the spinal dorsal horn and anterior cingulate cortex.J Neurochem 141(4):486-498. 2017 May

14. 御領憲治、古江秀昌
脳幹における痛みの抑制と慢性疼痛発現の機構、医学のあゆみ]260(2), 144-148, 2017-01-14 医歯薬出版
Publication list 2016(H28)
1. Katano T, Fukuda M, Furue H, Yamazaki M, Abe M, Watanabe M, Nishida K, Yao I, Yamada A, Hata Y, Okumura N, Nakazawa T, Yamamoto T, Sakimura K, Takao T, Ito S. Involvement of Brain-Enriched Guanylate Kinase-Associated Protein (BEGAIN) inChronic Pain after Peripheral Nerve Injury. eNeuro 3(5). pii:ENEURO.0110-16.2016. eCollection 2016 Sep-Oct. [PubMed]

2. Kozuka Y, Kawamata M, Furue H, Ishida T, Tanaka S, Namiki A, Yamakage M.
Changes in synaptic transmission of substantia gelatinosa neurons after spinal cord hemisection revealed by analysis using in vivo patch-clamp recording. Mol Pain 12.016 Aug 28 pii:1744806916665827.
doi: 10.1177/1744806916665827. Print 2016. [PubMed]

3. Kurabe M, Furue H, Kohno T.
Intravenous administration of lidocaine directly acts on spinal dorsal horn and produces analgesic effect: An in vivo patch-clamp analysis. Sci Rep 6:26253. 2016 May 18
doi: 10.1038/srep26253. [PubMed]

4. Naitou K, Nakamori H, Shiina T, Ikeda A, Nozue Y, Sano Y, Yokoyama T, Yamamoto Y, Yamada A, Akimoto N, Furue H, Shimizu Y.
Stimulation of dopamine D2-like receptors in the lumbosacral defaecation centre causes propulsivecolorectal contractions in rats. J Physiol 594(15):4339-50. 2016 Aug 1 doi:10.1113/JP272073. Epub 2016 Apr 28. [PubMed]

5. Tonomura S, Ebara S, Bagdasarian K, Uta D, Ahissar E, Meir I, Lampl I, Kuroda D, Furuta T, Furue H, Kumamoto K.
Errata to "Structure-function correlations of rat trigeminal primary neurons: Emphasis on club-like endings, a vibrissal mechanoreceptor". Proc Jpn Acad Ser B Phys Biol Sci. 92(2):76. 2016

6. Koga K, Li S, Zhuo M.
Metabotropic Glutamate Receptor Dependent Cortical Plasticity in Chronic Pain.
Curr Neuropharmacol 14(5):427-34. 2016[PubMed]
Publication list 2015(H27)
1. Tonomura S, Ebara S, Bagdasarian K, Uta D, Ahissar E, Meir I, Lampl I, Kuroda D,   Furuta T, Furue H, Kumamoto K.
Structure-function correlations of rat trigeminal primary neurons: Emphasis on club-like  endings, a vibrissal mechanoreceptor. Proc Jpn Acad Ser B Phys Biol Sci.   91(10):560-76. 2015
doi:10.2183/pjab.91.560. Erratum in: Proc Jpn Acad Ser B Phys  Biol Sci.2016;92(2):76. [PubMed]

2. Takayama Y, Uta D, Furue H, Tominaga M.
Pain-enhancing mechanism throughinteraction between TRPV1 and anoctamin 1 in sensory neurons. Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):5213-8.
doi: 10.1073/pnas.1421507112.[PubMed]

3. Koga K, Descalzi G, Chen T, Ko HG, Lu J, Li S, Son J, Kim T, Kwak C, Huganir RL, Zhao MG, Kaang BK, Collingridge GL, Zhuo M.
Coexistence of two forms of LTP in ACC provides a synaptic mechanism for the interactions between anxiety and chronic pain. Neuron. 2015 Jan 21;85(2):377-89. doi:10.1016/j.neuron.[PubMed]

4. Koga K, Liu MG, Qiu S, Song Q, O'Den G, Chen T, Zhuo M.
Impaired presynaptic long-term potentiation in the anterior cingulate cortex of Fmr1 knock-out mice.J Neurosci. 2015 Feb 4;35(5):2033-43. doi:10.1523/JNEUROSCI.2644-14.2015.[PubMed]

5. 山田彬博,古江秀昌(2015)神経障害性痛で生じるClイオン濃度勾配は,GABAで痛みが生じるほど大きな変化なのですか?.[LiSA]Vol.22 No.2 2015.130-131