Neuroscience Journal club

神経科学抄読会（大学院共通講義・一覧はこちらのＨＰより）
神経科学に関する最新の知見を紹介しています。
第1・第3・第５土曜日、9：00～10：30
担当：八木主任教授、廣瀬主任教授、古江主任教授
世話人：佐久間 理香
会場：教育研究棟６階　602セミナー室（会場変更の場合がありますのでご確認ください。）

タイトルをクリックするとPub medや雑誌ＨＰにリンクします。

2024.3.16　 601
 
2024.3.2　 601
 
2024.2.17　 601 ← ← ←NEW
1) Alleviation of neuropathic pain with neuropeptide Y requires spinal Npy1r interneurons that coexpress Grp. JCI Insight. 2023

2) Synaptic circuits involving gastrin-releasing peptide receptor-expressing neurons in the dorsal horn of the mouse spinal cord. Front Mol Neurosci. 2023
2024.2.3　 09-2
1) An ACC-VTA-ACC positive-feedback loop mediates the persistence of neuropathic pain and emotional consequences. Nat Neurosci. 2024

2) Injured sensory neurons-derived galectin-3 contributes to neuropathic pain via programming microglia in the spinal dorsal horn. Brain Behav Immun. 2024
2024.1.20　 09-2
1) Molecular anatomy of adult mouse leptomeninges. Neuron. 2023

2) Recovery of walking after paralysis by regenerating characterized neurons to their natural target region. Science. 2023
2024.1.6　 601
1) The β1-adrenergic receptor links sympathetic nerves to T cell exhaustion. Nature. 2023

2) Microglia promote remyelination independent of their role in clearing myelin debris. Cell Rep. 2023
2023.12/16　 601
1) Serotonin reduction in post-acute sequelae of viral infection. Cell. 2023

2) GAP43-dependent mitochondria transfer from astrocytes enhances glioblastoma tumorigenicity. Nat Cancer. 2023
2023.12.2　 休
2023.11.18　 休
 
2023.11.4　 505　
1) 3D architecture and a bicellular mechanism of touch detection in mechanosensory corpuscle.
Sci Adv. 2023

2) Effects of a neurokinin-1 receptor antagonist in the acute phase after thoracic spinal cord injury in a rat model. Front Mol Neurosci. 2023
2023.10.21　505
1) PIEZO2 in somatosensory neurons controls gastrointestinal transit. Cell.2023

2) NMDA Receptors at Primary Afferent–Excitatory Neuron Synapses Differentially Sustain Chemotherapy- and Nerve Trauma-Induced Chronic Pain. Jneurosci.2023
2023.10.7　 09-2
1) Revisiting differential control of sympathetic outflow by the rostral ventrolateral medulla.
Front Physiol. 2023

2) Dermal macrophages set pain sensitivity by modulating the amount of tissue NGF through an SNX25-Nrf2 pathway. Nat Immunol. 2023
2023.9.16　 09-2
1) Neuropeptide Y-expressing dorsal horn inhibitory interneurons gate spinal pain and itch signalling. Elife. 2023

2) Endogenous μ-opioid-Neuropeptide Y Y1 receptor synergy silences chronic postoperative pain in mice. PNAS Nexus. 2023
2023.9.2　　09-2
1) Representation and control of pain and itch by distinct prefrontal neural ensembles.
Neuron. 2023

2) Controlled delivery of a neurotransmitter-agonist conjugate for functional recovery after severe spinal cord injury. Nat Nanotechnol. 2023
2023.8.19 　休
2023.8.5　　602
1) A mesothelium divides the subarachnoid space into functional compartments.Science. 2023

2) Catechol-O-Methyltransferase Loss Drives Cell-Specific Nociceptive Signaling via the Enteric Catechol-O-Methyltransferase/microRNA-155/Tumor Necrosis Factor α Axis.
Gastroenterology. 2023
2023.7.15 　602
1) Excessive Mechanotransduction in Sensory Neurons Causes Joint Contractures.Science. 2023

2) Single cell atlas of spinal cord injury in mice reveals a pro-regenerative signature in spinocerebellar neurons. Nat Commun. 2022
2023.7.1 　09-2
1) The parabrachial nucleus elicits a vigorous corticosterone feedback response to the pro-inflammatory cytokine IL-1β. Neuron. 2023

2) Geometric constraints on human brain function. Nature. 2023
2023.6.17 505
1) Multimodal control of dendritic cell functions by nociceptors. Science. 2023

2) Distinct Local and Global Functions of Aβ Low-Threshold Mechanoreceptors in Mechanical Pain Transmission.bioRxiv [Preprint]. 2023
2023.6.3 　505
1) Role of TMEM100 in mechanically insensitive nociceptor un-silencing. Nat Commun.2023

2) Thoracic VGluT2+ Spinal Interneurons Regulate Structural and Functional Plasticity of Sympathetic Networks after High-Level Spinal Cord Injury. J Neurosci. 2022
2023.5.20　505
1) Identification of an essential spinoparabrachial pathway for mechanical itch. Neuron. 2023

2) Antibodies Against the Gastrin-releasing Peptide Precursor Pro-Gastrin-releasing Peptide Reveal Its Expression in the Mouse Spinal Dorsal Horn. Neuroscience. 2023
2023.5.6 　505
1) Piezo2 channels expressed by colon-innervating TRPV1-lineage neurons mediate visceral mechanical hypersensitivity. Neuron.2022

2) Elevated prelimbic cortex-to-basolateral amygdala circuit activity mediates comorbid anxiety-like behaviors associated with chronic pain. J Clin Invest. 2023
2023.4.15　505
1) Molecularly defined circuits for cardiovascular and cardiopulmonary control.Nature. 2022

2) Gut enterochromaffin cells drive visceral pain and anxiety. Nature. 2023
2023.4.1　505
1) An airway-to-brain sensory pathway mediates influenza-induced sickness. Nature. 2023

2) Periarteriolar spaces modulate cerebrospinal fluid transport into brain and demonstrate altered morphology in aging and Alzheimer's disease. Nat Commun. 2022
2023.3.18　休
2023.3.4 　 09-2
1) Hypothalamic warm-sensitive neurons require TRPC4 channel for detecting internal warmth and regulating body temperature in mice. Neuron. 2023

2) Spinal cord astrocytes regulate myocardial ischemia-reperfusion injury. Basic Res Cardiol. 2022
2023.2.18 　505
1) Spinal VGLUT3 lineage neurons drive visceral mechanical allodynia but not sensitized visceromotor reflexes. Neuron. 2023

2) Touch neurons underlying dopaminergic pleasurable touch and sexual receptivity. Cell. 2023
2023.2.4 　 09-2
1) Nerve growth factor transfer from cardiomyocytes to innervating sympathetic neurons activates TrkA receptors at the neuro-cardiac junction. J Physiol. 2022

2) Mechanisms and treatments of neuropathic itch in a mouse model of lymphoma.
J Clin Invest. 2023
2023.1.21 　505
1) LC-MS/MS-based arachidonic acid metabolomics in acute spinal cord injury reveals the upregulation of 5-LOX and COX-2 products. Free Radic Biol Med. 2022

2)Soft, bioresorbable coolers for reversible conduction block of peripheral nerves. Science. 2022
2023.1.7　　505
1) Layer-specific pain relief pathways originating from primary motor cortex. Science. 2022

2) Sensory neuron-expressed TRPC3 mediates acute and chronic itch. Pain. 2023
2022.12.17　09-2
1) HDAC2 in Primary Sensory Neurons Constitutively Restrains Chronic Pain by Repressing α2δ-1 Expression and Associated NMDA Receptor Activity. J Neurosci. 2022

2) Inferring and perturbing cell fate regulomes in human brain organoids. Nature. 2022
2022.11.5　09-2
1) Paxillin Is Required for Proper Spinal Motor Axon Growth into the Limb. J Neurosci. 2021

2) Nociceptor neurons direct goblet cells via a CGRP-RAMP1 axis to drive mucus production and gut barrier protection. Cell. 2022
2022.10.15　601
1)Quercetin alleviates kainic acid-induced seizure by inhibiting the Nrf2-mediated ferroptosis pathway. Free Radic Biol Med. 2022

2)Etv4 regulates nociception by controlling peptidergic sensory neuron development and peripheral tissue innervation. Development. 2022
2022.10.1　09-2
1)Mural Wnt/β-catenin signaling regulates Lama2 expression to promote neurovascular unit maturation. Development. 2022

2)Neuropathic pain caused by miswiring and abnormal end organ targeting. Nature. 2022
2022.9.17　09-2
1) Medullary kappa-opioid receptor neurons inhibit pain and itch through a descending circuit. Brain
. 2022

2) Metabolism regulator adiponectin prevents cardiac remodeling and ventricular arrhythmias via sympathetic modulation in a myocardial infarction model. Basic Res Cardiol. 2022
2022.9.3　505
1) TIGAR alleviates oxidative stress in brain with extended ischemia via a pentose phosphate pathway-independent manner. Redox Biol. 2022

2) Pre-Synaptic GABAA in NaV1.8+ Primary Afferents Is Required for the Development of Punctate but Not Dynamic Mechanical Allodynia following CFA Inflammation. Cells. 2022
2022.8.20　505
1) Miswiring of Merkel cell and pruriceptive C fiber drives the itch-scratch cycle. Sci Transl Med. 2022

2) Brain motor and fear circuits regulate leukocytes during acute stress. Nature. 2022
2022.8.6　09-2
1) Switch of serotonergic descending inhibition into facilitation by a spinal chloride imbalance in neuropathic pain. Sci Adv. 2022

2) Grpr expression defines a population of superficial dorsal horn vertical cells that have a role in both itch and pain. Pain. 2022
2022.7.16　09-2
2022.7.2　09-2
2022.6.18　505
2022.6.4　505
2022.5.21　505
2022.5.7　602
2022.4.16　09-2
1) Oncostatin M can sensitize sensory neurons in inflammatory pruritus. Sci Transl Med. 2021

2) Human and mouse trigeminal ganglia cell atlas implicates multiple cell types in migraine.
Neuron. 2022
2022.4.2　09-2
1) Social touch-like tactile stimulation activates a tachykinin 1-oxytocin pathway to promote social interactions. Neuron. 2022

2) Sympathectomy decreases pain behaviors and nerve regeneration by downregulating monocyte chemokine CCL2 in dorsal root ganglia in the rat tibial nerve crush model. Pain. 2022
2022.3.19　602
1) Human Astrocytes Exhibit Tumor Microenvironment-, Age-, and Sex-Related Transcriptomic Signatures.J Neurosci. 2022

2)Anti-inflammatory and antioxidant effects of astaxanthin following spinal cord injury in a rat animal model. Brain Res Bull. 2021
2022.3.5　09-2
1) Dorsal root ganglion stimulation of injured sensory neurons in rats rapidly eliminates their spontaneous activity and relieves spontaneous pain. Pain. 2021

2)Insular cortex neurons encode and retrieve specific immune responses. Cell. 2021
2022.2.19　602
1) Lunatic Fringe-GFP Marks Lamina-Specific Astrocytes That Regulate Sensory Processing. J Neurosci
. 2022

2) An injury-induced serotonergic neuron subpopulation contributes to axon regrowth and function restoration after spinal cord injury in zebrafish. Nat Commun. 2021
2022.2.5　09-2
1) Myocardial infarction reduces cardiac nociceptive neurotransmission through the vagal ganglia. JCI Insight. 2022

2) GnRH neurons recruit astrocytes in infancy to facilitate network integration and sexual maturation. Nat Neurosci. 2021
2022.1.15　602
1) A spinoparabrachial circuit defined by Tacr1 expression drives pain. Elife. 2021

2) Reverse-translational identification of a cerebellar satiation network. Nature. 2021
2021.12.18　602
1) Contribution of dorsal horn CGRPexpressing interneurons to mechanical sensitivity. Elife. 2021

2) Periostin-expressing Schwann cells and endoneurial cardiac fibroblasts contribute to sympathetic nerve fasciculation after birth. J Mol Cell Cardiol. 2021
2021.12.4　501
1) Synchronized cluster firing, a distinct form of sensory neuron activation, drives spontaneous pain. Neuron. 2021

2) Identification of a choroid plexus vascular barrier closing during intestinal inflammation. Science
. 2021
2021.11.20　09-2
1) Pain and depression comorbidity causes asymmetric plasticity in the locus coeruleus neurons. Brain
. 2021

2) Interferon-β suppresses inflammatory pain through activating µ-opioid receptor. Mol Pain. 2021
2021.11.6　09-2
1) A neuroanatomical basis for electroacupuncture to drive the vagal-adrenal axis. Nature. 2021

2) A photoswitchable GPCR-based opsin for presynaptic inhibition. Neuron. 2021
2021.10.16　201
1) Schwann Cells Provide Iron to Axonal Mitochondria and Its Role in Nerve Regeneration. J Neurosci
. 2021

2) IL-23/IL-17A/TRPV1 axis produces mechanical pain via macrophage-sensory neuron crosstalk in female mice. Neuron. 2021
2021.9.18　602
1) Sensory Neuron TLR4 mediates the development of nerve-injury induced mechanical hypersensitivity in female mice. Brain Behav Immun. 2021

2) α2δ-1 switches the phenotype of synaptic AMPA receptors by physically disrupting heteromeric subunit assembly. Cell Rep. 2021
2021.9.4　602
1) In vivo calcium imaging visualizes incision-induced primary afferent sensitization and its amelioration by capsaicin pretreatment. J Neurosci. 2021

2) Astrocytic interleukin-3 programs microglia and limits Alzheimer's disease. Nature. 2021
2021.8.21　602
1) Transient receptor potential canonical 5 mediates inflammatory mechanical and spontaneous pain in mice. Sci Transl Med. 2021

2) β2 adrenergic receptor mediates noradrenergic action to induce CREB phosphorylation in satellite glial cells of dorsal root ganglia to regulate visceral hypersensitivity. Pain. 2021
2021.8.7　09-2
1)Estrogens influence female itch sensitivity via the spinal gastrin-releasing peptide receptor neurons.
Proc Natl Acad Sci U S A. 2021

2) Alkyne-Tagged Dopamines as Versatile Analogue Probes for Dopaminergic System Analysis.
Anal Chem. 2021
2021.7.17　602
1) Pain and itch processing by subpopulations of molecularly diverse spinal and trigeminal projection neurons. Proc Natl Acad Sci U S A. 2021

2) Spinal Inhibitory Ptf1a-Derived Neurons Prevent Self-Generated Itch. Cell Rep. 2020
2021.7.3　09-2　
1)An orbitofrontal cortex to midbrain projection modulates hypersensitivity after peripheral nerve injury. Cell Rep. 2021

2)Long-lasting analgesia via targeted in situ repression of Na V 1.7 in mice. Sci Transl Med. 2021
2021.6.19　602
1)Posterior subthalamic nucleus (PSTh) mediates innate fear-associated hypothermia in mice.
Nat Commun. 2021

2)Sympathetic Input to Multiple Cell Types in Mouse and Human Colon Produces Region-Specific Responses. Gastroenterology. 2021
2021.6.5 　602
1) Inhibition of Itch by Hunger and AgRP Neuron Activity. Neuroscience. 2020

2)Neuronal enhancers are hotspots for DNA single-strand break repair.Nature. 2021
2021.5.29　602
1)Central opioid receptors mediate morphine-induced itch and chronic itch via disinhibition.
Brain. 2021

2)Early Life Nociception is Influenced by Peripheral Growth Hormone Signaling. J Neurosci. 2021
2021.5.15　602
1)Reactivation of the pluripotency program precedes formation of the cranial neural crest.
Science. 2021

2)BNSTAVGABA-PVNCRF Circuit Regulates Visceral Hypersensitivity Induced by Maternal Separation in Vgat-Cre Mice. Front Pharmacol. 2021
2021.5.1　602
1) Males and females exhibit distinct relationships between intervertebral disc degeneration and pain in a rat model. Sci Rep. 2020

2) USH2A is a Meissner’s corpuscle protein necessary for normal vibration sensing in mice and humans. Nat Neurosci. 2021
2021.4.17　09-2meeting room 　
1) Deletion of the Gene Encoding the NMDA Receptor GluN1 Subunit in Schwann Cells Causes Ultrastructural Changes in Remak Bundles and Hypersensitivity in Pain Processing. J Neurosci. 2020

2)Differential Coding of Itch and Pain by a Subpopulation of Primary Afferent Neurons. Neuron. 2020
2021.4.3　09-2meeting room
1) Behavioral and neurophysiological evidence suggests affective pain experience in octopus. iScience. 2021

2) A prefrontal–paraventricular thalamus circuit requires juvenile social experience to regulate
adult sociability in mice. Nat Neurosci. 2020
2021.3.6　09-2meeting room　
1)dmPFC-vlPAG projection neurons contribute to pain threshold maintenance and antianxiety behaviors. J Clin Invest. 2020

2)Nociceptive afferent phenotyping reveals that transient receptor potential ankyrin 1 promotes cold pain through neurogenic inflammation upstream of the neurotrophic factor receptor GFRα3 and the menthol receptor transient receptor potential melastatin 8. Pain. 2021
2021.2.20　602
1) STING controls nociception via type I interferon signalling in sensory neurons. Nature. 2021

2)Morphine acts on spinal dynorphin neurons to cause itch through disinhibition.
Sci Transl Med. 2021
2021.2.6　09-2meeting room
1) Neuropathic pain generates silent synapses in thalamic projection to anterior cingulate cortex.
Pain. 2020

2)Neurotropin exerts neuroprotective effects after spinal cord injury by inhibiting apoptosis and modulating cytokines. J Orthop Translat. 2020
2021.1.30　9-1（9号館5階）
1)Sensory Experience Engages Microglia to Shape Neural Connectivity through a Non-Phagocytic Mechanism. Neuron. 2020

2) Local immune response to food antigens drives meal-induced abdominal pain. Nature. 2021
2021.1.16　602 　
1) Kif3a deletion prevents primary cilia assembly on oligodendrocyte progenitor cells, reduces oligodendrogenesis and impairs fine motor function. Glia.2020

2) Ablation of spinal cord estrogen receptor α‐expressing interneurons reduces chemically induced modalities of pain and itch. J Comp Neurol. 2020
2020.12.19　09-2meeting room
1) The Neurokinin-1 Receptor is Expressed with Gastrin-Releasing Peptide Receptor in Spinal Interneurons and Modulates ItchJ. Neurosci. 2020

2) Decoding Cellular Mechanisms for Mechanosensory Discrimination. Neuron. 2020
2020.12.5　09-2meeting room
1) Gut microbiota depletion by chronic antibiotic treatment alters the sleep/wake architecture and sleep EEG power spectra in mice.Sci Rep. 2020

2)Ablation of spinal cord estrogen receptor α-expressing interneurons reduces chemically induced modalities of pain and itch. J Comp Neurol. 2020
2020.11.21　休
2020.11.7　9-3
1)Low-threshold mechanosensitive VGLUT3-lineage sensory neurons mediate spinal inhibition of itch by touch. JNEUROSCI.2020

2)Schwann cell p75 neurotrophin receptor modulates small fiber degeneration in diabetic neuropathy. Glia. 2020
2020.10.31　09-2meeting room
1) Spinal astrocytes in superficial laminae gate brainstem descending control of mechanosensory hypersensitivity. Nat Neurosci. 2020

2) Increased CXCL13 and CXCR5 in Anterior Cingulate Cortex Contributes to Neuropathic Pain-Related Conditioned Place Aversion. Neurosci Bull. 2019
 
2020.10.17　09-2meeting room
1) Depression and Social Defeat Stress Are Associated with Inhibitory Synaptic Changes in the Nucleus Accumbens. J NEUROSCI.2020

2) A Unique Collateral Artery Development Program Promotes Neonatal Heart Regeneration.
Cell. 2019
2020.10.3　09-2meeting room
1) Microglial Remodeling of the Extracellular Matrix Promotes Synapse Plasticity. Cell 2020

2)Selective-cold output through a distinct subset of lamina I spinoparabrachial neurons. PAIN 2020
2020.9.19 　9-４　
1)Sodium channel Nav1.6 in sensory neurons contributes to vincristine-induced allodynia.BRAIN.2020

2)Spinal Wnt5a Plays a Key Role in Spinal Dendritic Spine Remodeling in Neuropathic and Inflammatory Pain Models and in the Proalgesic Effects of Peripheral Wnt3a. JNEUROSCI.2020
2020.9.5 　09-2meeting room
1)ACE2 expression in human dorsal root ganglion sensory neurons: implications for SARS-CoV-2 virus-induced neurological effects. bioRxiv. 2020

2) Fractalkine-Dependent Microglial Pruning of Viable Oligodendrocyte Progenitor Cells Regulates
Myelination. Cell Reports. 2020
2020.8.29 　9-3
1) FTY720 Attenuates Neuropathic Pain after Spinal Cord Injury by Decreasing Systemic and Local Inflammation in a Rat Spinal Cord Compression Model. J Neurotrauma. 2020

2) Importin α3 regulates chronic pain pathways in peripheral sensory neurons. Science. 2020
2020.8.1 　9-4 (9号館５階）　
1) Selective Induction of Human Autonomic Neurons Enables Precise Control of Cardiomyocyte Beating. Sci Rep. 2020
2020.7.18　9-3
1) Type I Interferons Act Directly on Nociceptors to Produce Pain Sensitization: Implications for Viral Infection-Induced Pain. J Neurosci. 2020

2) Studies on the mechanism of general anesthesia. PNAS.2020
2020.7.4 　 9-3
1)Mapping Cortical Integration of Sensory and Affective Pain Pathways. Curr Biol. 2020.

2)Group II Metabotropic Glutamate Receptor Expressing Neurons in Anterior Cingulate Cortex Become Sensitized After Inflammatory and Neuropathic Pain . Mol Pain. 2020
2020.6.20　9-3
1) Behavioral characterization of a CRISPR-generated TRPA1 knockout rat in models of pain, itch, and asthma. Sci Rep. 2020

2)TACAN Is an Ion Channel Involved in Sensing Mechanical Pain. Cell. 2020
2020.6.6　　9-3 　
1) Exploration of Sensory and Spinal Neurons Expressing Gastrin-Releasing Peptide in Itch and Pain Related Behaviors. Nat Commun . 2020

2) γδ T Cells and Adipocyte IL-17RC Control Fat Innervation and Thermogenesis. Nature. 2020
2020.4.4　09-2
1) Epigenetic upregulation of acid-sensing ion channel 1 contributes to gastric hypersensitivity in adult offspring rats with prenatal maternal stress. Pain. 2019

2) An amygdalo-parabrachial pathway regulates pain perception and chronic pain. J Neurosci. 2020
2020.3.21　602
1) Nonionotropic Action of Endothelial NMDA Receptors on Blood-Brain Barrier Permeability via Rho/ROCK-Mediated Phosphorylation of Myosin. J Neurosci. 2020

2) Relationship of Inflammatory Cytokines From M1-Type Microglia/Macrophages at the Injured Site and Lumbar Enlargement With Neuropathic Pain After Spinal Cord Injury in the CCL21 Knockout (plt) Mouse. Front Cell Neurosci. 2019
2020.3.7　　　9-3（9号館5階）
1) Dorsal root ganglion macrophages contribute to both the initiation and persistence of neuropathic pain. Nat Commun. 2020
2020.2.29　　602
1) TRPA1 channel contributes to myocardial ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol. 2019

2) Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer's disease.Nature. 2020
2020.2.15　　神経生理カンファ教員研究室（教育研究棟10階）
1) Synapse-specific opioid modulation of thalamo-cortico-striatal circuits. Elife. 2019

2) Deep Sequencing of Somatosensory Neurons Reveals Molecular Determinants of Intrinsic
Physiological Properties. Neuron. 2019
2020.2.1　　　9-2（9号館5階）
1)Dual and Opposing Functions of the Central Amygdala in the Modulation of Pain. Cell Rep. 2019
2020.1.18　　09-2（ミーティングルーム）
1)Macrophage Toll-like Receptor 9 Contributes to Chemotherapy-Induced Neuropathic Pain in Male Mice. J Neurosci. 2019
2019.12.21　神経生理カンファ教員研究室（教育研究棟10階）
1) Activation of the Intrinsic Pain Inhibitory Circuit from the Midcingulate Cg2 to Zona Incerta Alleviates Neuropathic Pain. J Neurosci. 2019

2)Effects of Serotonin and Slow-Release 5-Hydroxytryptophan on Gastrointestinal Motility in a Mouse Model of Depression. Gastroenterology. 2019
2019.12.7 　　9-1
1) Activation of pruritogenic TGR5, MrgprA3, and MrgprC11 on colon-innervating afferents induces visceral hypersensitivity. JCI Insight. 2019

2) Schwann cells expressing nociceptive channel TRPA1 orchestrate ethanol-evoked neuropathic pain in mice. J Clin Invest. 2019
2019.11.16　神経生理カンファ教員研究室（教育研究棟10階）
1)Neonatal Injury Alters Sensory Input and Synaptic Plasticity in GABAergic Interneurons of the Adult Mouse Dorsal Horn. J Neurosci. 2019

2)Spinal somatostatin-positive interneurons transmit chemical itch.Pain. 2019
2019.11. 2　　602
1) Conserved cell types with divergent features in human versus mouse cortex. Nature. 2019

2)Estrogen alleviates neuropathic pain induced after spinal cord injury by inhibiting microglia and astrocyte activation. Biochim Biophys Acta Mol Basis Dis. 2018
2019.10.19　神経生理カンファ教員研究室（教育研究棟10階）
1) How Gastrin-Releasing Peptide Opens the Spinal Gate for Itch. Neuron. 2019

2) Tanycytes Regulate Lipid Homeostasis by Sensing Free Fatty Acids and Signaling to Key Hypothalamic Neuronal Populations via FGF21 Secretion. Cell Metab. 2019
2019.10.5 　 303ABセミナー室（教育研究棟３階）
1) Laminin α2 controls mouse and human stem cell behaviour during midbrain dopaminergic neuron development. Development. 2019

2) Specialized cutaneous Schwann cells initiate pain sensation. Science. 2019
2019.9.21 　 神経生理カンファ教員研究室（教育研究棟10階）
1) A neural circuit for comorbid depressive symptoms in chronic pain. Nat Neurosci. 2019

2) Effect of Adenylyl Cyclase Type 6 on Localized Production of cAMP by b-2 Adrenoceptors in Human Airway Smooth-Muscle Cellss. JPET 2019
2019.9.7 　　602
1) Long-Term Stress Disrupts the Structural and Functional Integrity of GABAergic Neuronal Networks in the Medial Prefrontal Cortex of Rats. Front Cell Neurosci. 2018
2019.8.31 　 602
1) HIF-1α is required for development of the sympathetic nervous system. Proc Natl Acad Sci U S A. 2019

2) Sympathoexcitation in response to cardiac and pulmonary afferent stimulation of TRPA1 channels is attenuated in rats with chronic heart failure. Am J Physiol Heart Circ Physiol. 2019
2019.8.3　 9-1（9号館5階）
1) Nppb Neurons Are Sensors of Mast Cell-Induced Itch. Cell Rep. 2019

2) Aluminum Ingestion Promotes Colorectal Hypersensitivity in Rodents. Cell Mol Gastroenterol Hepatol. 2018
2019.7.20　６０２
1) A Subpopulation of Amygdala Neurons Mediates the Affective Component of Itch. J Neurosci. 2019

2) A population of gut epithelial enterochromaffin cells is mechanosensitive and requires Piezo2 to convert force into serotonin release. Proc Natl Acad Sci U S A. 2018
2019.7.6　 神経生理カンファ教員研究室（教育研究棟10階）
1) Extrinsic Primary Afferent Neurons Link Visceral Pain to Colon Motility Through a Spinal Reflex in Mice.　Gastroenterology. 2019

2) Nonhistaminergic and mechanical itch sensitization in atopic dermatitis. Pain. 2017
2019.6.29　9－3(9号館5階）
1) Progenitors from the central nervous system drive neurogenesis in cancer. Nature. 2019

2) FBXW5 reduction alleviates spinal cord injury (SCI) by blocking microglia activity: A mechanism involving p38 and JNK. Biochem Biophys Res Commun. 2019
2019.6.15　６０２
1) Is Optogenetic Activation of Vglut1-positive Aβ Low-Threshold Mechanoreceptors Sufficient to Induce Tactile Allodynia in Mice after Nerve Injury? J Neurosci. 2019

2) Mispositioned Neurokinin-1 receptor-expressing neurons underlie heat hyperalgesia in Disabled-1 mutant mice. eNeuro. 2019
2019.6.1　６０２
1）Hyperactivity of Anterior Cingulate Cortex Areas 24a/24b Drives Chronic Pain-Induced Anxiodepressive-like Consequences.J Neurosci. 2018

2) Endothelial Adora2a Activation Promotes Blood-Brain Barrier Breakdown and Cognitive Impairment in Mice with Diet-Induced Insulin Resistance.J Neurosci. 2019
2019.4.20 　６０２
1) Spinal dorsal horn astrocytes release GABA in response to synaptic activation. J Physiol. 2018

2) Slide-seq: A scalable technology for measuring genome-wide expression at high spatial　resolution. Science. 2019
2019.4. 6 　 ６０２
1) Primary Afferent-Derived BDNF Contributes Minimally to the Processing of Pain and Itch.
eNeuro. 2018

2) Kappa opioid signaling in the central nucleus of the amygdala promotes disinhibition and aversiveness of chronic neuropathic pain. Pain. 2019
2019.3.30 　 ６０２
1)Morphological and functional properties distinguish the substance P and gastrin-releasing peptide subsets of excitatory interneuron in the spinal cord dorsal horn.Pain. 2019

2)DPP-4 inhibition enhanced renal tubular and myocardial GLP-1 receptor expression decreased in CKD with myocardial infarction. BMC Nephrol. 2019
2019.3.16 　６０２
1) α6 and β1 Integrin Heterodimer Mediates Schwann Cell Interactions with Axons and Facilitates Axonal Regeneration after Peripheral Nerve Injury. Neuroscience. 2018

2) Metformin prevents colonic barrier dysfunction by inhibiting mast cell activation in maternal separation-induced IBS-like rats. Neurogastroenterol Motil. 2019
2019.３.２ 　 ９－３
1) Constitutive μ-opioid receptor activity leads to long-term endogenous analgesia and dependence.Science. 2013

2) Optogenetic Activation of Colon Epithelium of the Mouse Produces High-Frequency Bursting in Extrinsic Colon Afferents and Engages Visceromotor Responses. J Neurosci. 2018
2019.2.16　教育研究棟　古江研セミナー室
1) A Mast-Cell-Specific Receptor Mediates Neurogenic Inflammation and Pain.Neuron. 2019

2) Alendronate Attenuates Spinal Microglial Activation and Neuropathic Pain. J Pain. 2016
2019.2.2　 教育研究棟　古江研セミナー室
1) Psychophysical and vasomotor evidence for interdependency of TRPA1 and TRPV1-evoked nociceptive responses in human skin: an experimental study. Pain. 2018

2) Claudin-1-Dependent Destabilization of the Blood-Brain Barrier in Chronic Stroke. J Neurosci. 2019
2019.1.19　教育研究棟　古江研セミナー室
1）Microglia Promote Increased Pain Behavior through Enhanced Inflammation in the Spinal Cord During Repeated Social Defeat Stress. J Neurosci. 2018

2) Inhibition of α2C-adrenoceptors ameliorates cisplatin-induced acute renal failure in rats.
Eur J Pharmacol. 2018
2018.12.15
1) Pathogenesis of abdominal pain in bowel obstruction: Role of mechanical stress-induced upregulation of nerve growth factor in gut smooth muscle cells. Pain. 2017

2)Panoptic vDISCO imaging reveals neuronal connectivity, remote trauma effects and meningeal
vessels in intact transparent mice. bioRxiv. 2018　
2018.12.1　
１）Neural pathways in medial septal cholinergic modulation of chronic pain: distinct contribution of the anterior cingulate cortex and ventral hippocampus. Pain. 2018

2) Microglia Play an Active Role in Obesity-Associated Cognitive Decline. J Neurosci. 2018
2018.11.17　
1) Merkel Cells Activate Sensory Neural Pathways through Adrenergic Synapses. Neuron.2018

2) A dopaminergic switch for fear to safety transitions. Nat Commun. 2018
2018.10.20
1) GPR37 regulates macrophage phagocytosis and resolution of inflammatory pain. J Clin Invest. 2018

2) A Tyrosine Switch on NEDD4-2 E3 Ligase Transmits GPCR Inflammatory Signaling.Cell Rep. 2018
2018.10.6
1) ACC to Dorsal Medial Striatum Inputs Modulate Histaminergic Itch Sensation. J Neurosci. 2018

2)TRPV4 Channel Signaling in Macrophages Promotes Gastrointestinal Motility via Direct Effects on Smooth Muscle Cells. Immunity. 2018
2018.9.29
1) Multiple roles of integrin-α3 at the neuromuscular junction. J Cell Sci. 2017

2)A gut-brain neural circuit for nutrient sensory transduction.Science. 2018
2018.9.1
1) Rapamycin suppresses microglial activation and reduces the development of neuropathic pain after spinal cord injury.J Orthop Res. 2017

2) Developmental origins of functional dyspepsia-like gastric hypersensitivity in rats.Gastroenterology. 2013
2018.8.4
この日は会場が変更になります。（教育研究棟 10F 神経生理カンファ・教員研究室）
1) Central inhibition of granulocyte-macrophage colony-stimulating factor is analgesic in experimental neuropathic pain.Pain. 2018

2) Neural-specific deletion of the focal adhesion adaptor protein paxillin slows migration speed and delays cortical layer formation.Development. 2017
2018.7.21
1) A Combination of Ontogeny and CNS Environment Establishes Microglial Identity.Neuron. 2018
2018.7.7
1)Loss of NHERF-1 expression prevents dopamine-mediated Na-K-ATPase regulation in renal proximal tubule cells from rat models of hypertension: aged F344 rats and spontaneously hypertensive rats.Am J Physiol Cell Physiol. 2017

2)Ca2+-binding protein NECAB2 facilitates inflammatory pain hypersensitivity.J Clin Invest. 2018
2018.6.30
1) Fractone Bulbs Derive from Ependymal Cells and Their Laminin Composition Influence the Stem Cell Niche in the Subventricular Zone.J Neurosci. 2018

2)Functional and Molecular Characterization of Mechanoinsensitive ‘‘Silent’’ Nociceptors.Cell Rep. 2017
2018.6.2 この日は会場が変更になります。（教育研究棟 601）
1) Circuit dissection of the role of somatostatin in itch and pain.Nat Neurosci. 2018

2) Functional Divergence of Delta and Mu Opioid Receptor Organization in CNS Pain Circuits.
Neuron. 2018
2018.4.21
1) Dynamics of neuroeffector coupling at cardiac sympathetic synapses.J Physiol. 2018
2) A neuronal mechanism underlying decision-making deficits during hyperdopaminergic states.Nature Commun. 2018
2018.4.7
1) Rapid Turnover of Cortical NCAM1 Regulates Synaptic Reorganization after Peripheral Nerve Injury.Cell Rep 2018

2) A TRP channel trio mediates acute noxious heat sensing. Nature 2018
2018.3.17
1) A Unique Homeostatic Signaling Pathway Links Synaptic Inactivity to Postsynaptic mTORC1.J Neurosci 2018
2) A central neural circuit for itch sensation.Secience 2018
2018.2.17
1) Schwann cell TRPA1 mediates neuroinflammation that sustains macrophage-dependent neuropathic pain in mice.Nat Commun 2017
2) Activation of Myofibroblast TRPA1 by Steroids and Pirfenidone Ameliorates Fibrosis in Experimental Crohn's Disease.Cmgh 2018
2018.2.3
1) Interleukin-4 mediates the analgesia produced by low-intensity exercise in mice with neuropathic pain. Pain 2018
2) Lanthionine ketimine ester promotes locomotor recovery after spinalcord injury by reducing neuroinflammation and promoting axongrowth.BBRC 2017
2018.1.20
1) A craniofacial-specific monosynaptic circuit enables heightened affective pain. Nat Neurosci 2017
2) CNS Neurons Deposit Laminin α5 to Stabilize Synapses.Cell Rep 2017