兵庫医科大学 内科学総合診療科学

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１.著書

1)英文

  1. Yamamoto T, Shinmura K. Chapter 17: Targeting sirtuins to modulate energy metabolism in heart disease. Sirtuin Biology in Medicine. (eds. Maiese K), Academic Press Elsevier, 2021 Mar 5th, p285-293.
  2. Shinmura K. Chapter 17: Dietary restriction in the epigenomic regulation of cardiovascular diseases. Nutritional Epigenomics. Translational epigenetics series Volume 14. (eds. Ferguson BS) Academic Press Elsevier, 2019 Aug 1st, p269-287.　

2)和文

  1. 新村　健：脳のアンチエイジング。アンチエイジング診療23のエッセンス。医学のあゆみBooks　(堀江重郎編) 医歯薬出版株式会社, 2019, p8-13.

2. 総説

1)英文

  1. Shinmura K. Frailty, heart failure, and cognitive impairment: a triangle in elderly people. Heart Metab 2018;76:8-12.
  2. Kusunoki H, Shinmura K. Association between glycative stress, frailty, and sarcopenia. Glycative Stress Res 2017;4(4):292-298.
  3. Shinmura K. Cardiac senescence, heart failure, and frailty: a triangle in elderly people. Keio J Med 65(2):25-32,2016.

2)和文

  1. 楠博, 新村健 高齢者の心不全 ニュートリションケア 13(6): 523-527, 2020.
  2. 新村健 特集 総合診療から高齢者医療の在り方を探る 序文 Geriatric Medicine（老年医学） 58(7): 575-576, 2020.
  3. 新村健 『日本を襲ったスペイン・インフルエンザ』著者, 速水融先生との思い出 アンチ・エイジング医学 16(3): 382-382, 2020.
  4. 新村 健. 老年期における認知機能障害対策:フレイル、MCIを中心に. 兵庫県医師会医学雑誌 2020;63(1):41-43.
  5. 新村 健. 総合診療専門医と老年病専門医. 老年内科 2020;2(3):358-363.
  6. 楠　博、新村　健：高齢者心不全におけるフレイル、認知機能障害対策。日本老年医学会雑誌　2019;56(2):107-114.
  7. 新村　健： 老化を仲介する液性因子。日本老年医学会雑誌　53(1):10-17,2016.

3.原著

1)英文

  1. Yamamoto T, Endo J, Kataoka M, Matsuhashi T, Katsumata Y, Shirakawa K, Isobe S, Moriyama H, Goto S, Shimanaka Y, Kono N, Arai H, Shinmura K, Fukuda K, Sano M. Palmitate induces cardiomyocyte death via inositol requiring enzyme-1 (IRE1)-mediated signaling independent of X-box binding protein 1 (XBP1). Biochem Biophys Res Commun. 2020 May 21;526(1):122-127.
  2. Yamazaki H, Kuroiwa T, Shinmura K, Yukioka M, Murata N. Prevalence of anti-cyclic citrullinated peptide antibodies in patients with spondyloarthritis: A retrospective study. Mod Rheumatol. 2021 Mar;31(2):458-461.
  3. Nagai K, Tamaki K, Kusunoki H, Wada Y, Tsuji S, Itoh M, Sano K, Amano M, Hayashitani S, Yokoyama R, Yonezawa R, Kamitani T, Shinmura K. Physical frailty predicts the development of social frailty: a prospective cohort study. BMC Geriatr. 2020 Oct 14;20(1):403.
  4. Hasegawa Y, Sakuramoto-Sadakane A, Yoshida M, Yoshikawa M, Nozaki S, Hikasa S, Horii N, Sugita H, Ono T, Shinmura K, Kishimoto H. Basic survey for the prevention of intraoral residual medication in older adults: A pilot study. Gerodontology. 2020 Mar;37(1):93-96.
  5. Kusunoki H, Tsuji S, Kusukawa T, Wada Y, Tamaki K, Nagai K, Itoh M, Sano K, Amano M, Maeda H, Sugita H, Hasegawa Y, Kishimoto H, Shimomura S, Shinmura K. Relationships between cystatin C- and creatinine-based eGFR in Japanese rural community- dwelling older adults with sarcopenia. Clin Exp Nephrol. 2021 Mar;25(3):231-239.
  6. Hasegawa Y, Sakuramoto-Sadakane A, Nagai K, Tamaoka J, Oshitani M, Ono T, Sawada T, Shinmura K, Kishimoto H. Does Oral Hypofunction Promote Social Withdrawal in the Older Adults? A Longitudinal Survey of Elderly Subjects in Rural Japan. Int J Environ Res Public Health. 2020 Nov 30;17(23):8904.
  7. Tsuji S, Shinmura K, Nagai K, Wada Y, Kusunoki H, Tamaki K, Ito M, Sano K, Amano M, Hasegawa Y, Kishimoto H, Maruo K, Iseki T, Tachibana T. Low back pain is closely associated with frailty but not with sarcopenia: Cross-sectional study of rural Japanese community-dwelling older adults. Geriatr Gerontol Int. 2021 Jan;21(1):54-59.
  8. Kusunoki H, Iwashima Y, Kawano Y, Ohta Y, Hayashi SI, Horio T, Shinmura K, Ishimitsu T, Yoshihara F. Associations between Arterial Stiffness Indices and Chronic Kidney Disease Categories in Essential Hypertensive Patients. Am J Hypertens. 2020 Oct 8:hpaa163. doi: 10.1093/ajh/hpaa163.
  9. Nagai K, Matsuzawa R, Wada Y, Tsuji S, Itoh M, Sano K, Amano M, Tamaki K, Kusunoki H, Shinmura K. Impact of Isotemporal Substitution of Sedentary Time With Physical Activity on Sarcopenia in Older Japanese Adults. J Am Med Dir Assoc. 2021 Mar 12:S1525-8610(21)00207-3.
  10. Komatsu R, Nagai K, Hasegawa Y, Okuda K, Okinaka Y, Wada Y, Tsuji S, Tamaki K, Kusunoki H, Kishimoto H, Shinmura K. Association between physical frailty subdomains and oral frailty in community-dwelling older adults. Int J Environ Res Public Health. in press.
  11. Kusunoki H, Iwashima Y, Kawano Y, Hayashi S, Kishida M, Horio T, Shinmura K, Yoshihara F. Association Between Circadian Hemodynamic Characteristics and Target Organ Damage in Patients With Essential Hypertension. Am J Hypertens. 2019 Jun 18. pii: hpz088. [Epub ahead of print]
  12. Yamamoto T, Endo J, Kataoka M, Matsuhashi T, Katsumata Y, Shirakawa K, Yoshida N, Isobe S, Moriyama H, Goto S, Yamashita K, Ohta-Nakanishi T, Nakanishi H, Shimanaka Y, Kono N, Shinmura K, Arai H, Fukuda K, Sano M. Sirt1 counteracts decrease in membrane phospholipid unsaturation and diastolic dysfunction during saturated fatty acid overload. J Mol Cell Cardiol. 2019 May 27:133:1-11. [Epub ahead of print]
  13. Hasegawa Y, Sakuramoto A, Sugita H, Hasegawa K, Horii N, Sawada T, Shinmura K, Kishimoto H. Relationship between oral environment and frailty among older adults dwelling in a rural Japanese community: a cross-sectional observational study. BMC Oral Health 2019;19(1):23.
  14. Tamaki K, Kusunoki H, Tsuji S, Wada Y, Nagai K, Itoh M, Sano K, Amano M, Maeda H, Hasegawa Y, Kishimoto H, Shimomura S, Shinmura K. Relationship between dietary habit and frailty in rural Japanese community-dwelling older adults: Cross-sectional observation study using a brief self-administered dietary history questionnaire. Nutrients 2018;10(12).pii E1982.
  15. Yamamoto T, Endo J, Kataoka M, Katsumata Y, Shirakawa K, Yoshida N, Isobe S, Moriyama H, Goto S, Yamashita K, Shinmura K, Fukuda K, Sano M. Decrease in membrane phospholipids unsaturation correlates with myocardial diastolic dysfunction. PLoS One 2018;13(12):20208396.
  16. Nagai K, Tamaki K, Kusunoki H, Wada Y, Tsuji S, Ito M, Sano K, Amano M, Shimomura S, Shinmura K. Isotemporal substitution of sedentary time with physical activity and its associations with frailty status. Clin Interv Aging 2018;13:1831-1836.
  17. Kusunoki H, Iwashima Y, Kawano Y, Hayashi SI, Kishida M, Horio T, Shinmura K, Yoshihara F. Circadian hemodynamic characteristics in hypertensive patients with primary aldosteronism. J Hypertens. 2018;36(11):2260-2268.
  18. Nagai K, Miyamato T, Okamae A, Tamaki A, Fujioka H, Wada Y, Uchiyama Y, Shinmura K, Domen K. Physical activity combined with resistance training reduces symptoms of frailty in older adults: A randomized controlled trial. Arch Gerontol Geriatr. 2018;76:41-47.
  19. Kusunoki H, Tsuji S, Wada Y, Fukai M, Nagai K, Itoh M, Sano K, Tamaki K, Ohta Y, Amano M, Maeda H, Hasegawa Y, Kishimoto H, Shimomura H, Yoshikawa H, Shinmura K. Relationship between sarcopenia and the serum creatinine/cystatin C ratio in Japanese rural community-dwelling older adults. JCSM Clin Rep. 2018;3(1): e0057.
  20. Shirakawa K, Yan X, Shinmura K, Endo J, Kataoka M, Katsumata Y,Yamamoto T, Anzai A, Isobe S, Yoshida N, Itoh H, Manabe I, Sekai M, Hamazaki Y, Fukuda K, Minato N, Sano M. Obesity accelerates T-cell senescence in visceral adipose tissue. J Clin Invest. 126(12):4626-39,2016.
  21. Yamamoto T, Tamaki K, Shirakawa K, Ito K, Yan X, Katsumata Y, Anzai A, Matsuhashi T, Endo J, Inaba T, Tsubota K, Sano M, Fukuda K, Shinmura K, Cardiac Sirt1 mediates the cardioprotective effect of caloric restriction by suppressing local complement system activation after ischemia/reperfusion. Am J Physiol Heart Circ Physiol. 310(8):H1003-14,2016.
  22. Tamura Y, Matsuhashi T, Hishiki T, Zhou H, Ono T, Kaneda R, Iso T, Yamaguchi A, Endo J, Katsumata Y, Atsushi A, Yamamoto T, Shirakawa K, Yan X, Shinmura K, Suematsu M, Fukuda K, Sano M. Neural crest-derived resident cardiac cells contribute to the restoration of adrenergic function of transplanted heart in rodent. Cardiovasc Res. 109(3):350-7,2016.
  23. Nakano S, Ishii I, Shinmura K, Tamaki K, Hishiki T, Akahoshi N, Ida T, Nakanishi T, Kamata S, Kumagai Y, Akaike T, Fukuda K, Sano M, Suematsu M. Hyperhomocysteinemia abrogates fasting-induced cardioprotection against ischemia/reperfusion by limiting bioavailability of hydrogen sulfide anions. J Mol Med (Berl). 93(8):879-89,2015.
  24. Matsuhashi T, Hishiki T, Zhou H, Ono T, Kaneda R, Iso T, Yamaguchi A, Endo J, Katsumata Y, Atsushi A, Yamamoto T, Shirakawa K, Yan X, Shinmura K, Suematsu M, Fukuda K, Sano M. Activation of pyruvate dehydrogenase by dichloroacetate has the potential to induce epigenetic remodeling in the heart. J Mol Cell Cardiol. 82:116-24,2015.
  25. Shinmura K, Tamaki K, Ito K, Yan X, Yamamoto T, Katsumata Y, Matsuhashi T, Sano M, Fukuda K, Suematsu M, Ishii I. Indispensable role of endothelial nitric oxide synthase in caloric restriction-induced cardioprotection against ischemia/reperfusion injury. Am J Physiol Heart Circ Physiol. 308(8):H894-903,2015.
  26. Anzai A, Shimoda M, Endo J, Kohno T, Katsumata Y, Matsuhashi T, Yamamoto T, Ito K, Yan X, Shirakawa K, Shimizu-Hirota R, Yamada Y, Ueha S, Shinmura K, Okada Y, Fukuda K, Sano M. Adventitial CXCL1/G-CSF expression in response to acute aortic dissection triggers local neutrophil recruitment and activation leading to aortic rupture. Circ Res. 116(4):612-23,2015.

2)和文

  1. Murakami-Nakayama M, Yasuda M, Shinmura K, Amano M. 農村地域で運転に影響を及ぼす薬剤を服用している高齢者における運転状態の調査(Survey Regarding the Driving Status of Elderly Persons in a Rural Area Taking Drugs that Influence Driving). 医療薬学 2020;46(4):205-210.
  2. 長谷川陽子，堀井宣秀，櫻本亜弓, 杉田英之, 長谷川香奈、小野高裕，永井宏達，新村　健，岸本裕充。丹波圏域在住高齢者における転倒リスクと歯/咬合との関連性。老年歯科医学　32(4):468-476,2018.

4. その他の論文

4-1. Research Letter

1)英文

  1. 1. Nagai K, Sano K, Tamaki K, Kusunoki H, Wada Y, Tsuji S, Itoh M, Shimomura S, Amano N, Okada M, Kawaoka M, Yukimitsu S, Shinmura K. Severe apathy as a risk factor for falls in older adults with frailty symptoms. J Am Med Dir Assoc. 2019 Jul 3. pii: S1525-8610(19)30440-2. [Epub ahead of print].

4-2. 解説等

1)和文

  1. 新村　健：リハビリテーション医療に必要な老年医学のエッセンス。Japanese Journal of Rehabilitation Medicine　2019 (印刷中)
  2. 新村　健：私の目指す老年内科：Integrated Geriatric Medicineに向けて。老年内科 2019 (印刷中)
  3. 新村　健：フレイルモデルに基づく高齢者診療のすゝめ。兵庫県医師会雑誌 2019;61(2):1-3.
  4. 太田好紀、新村　健： 周術期に留意すべき凝固異常：後天性血栓性素因－肥満。Thrombosis Medicine 2019;9(1):56-59.
  5. 楠　博、　新村　健：酸化ストレス。日本臨床増刊号　老年医学の進歩（上）　2018;76(S6):131-135.
  6. 江口明世、新村　健：スポーツと心臓：高齢者スポーツと心臓。スポーツ医学 2018;35(6):602-607.
  7. 新村　健：カロリー制限?タンパク制限？カロリー制限の立場より。 アンチ･エイジング医学－日本抗加齢医学会雑誌　13(2):254-258,2017.
  8. 楠　博、新村　健： 静脈血栓症の危険因子　肥満。日本臨床増刊号　動脈・静脈の疾患（上）　75(Suppl5):116-119,2017.
  9. 新村　健：朝食を摂る?摂らない？朝食を摂らない立場より。 アンチ･エイジング医学－日本抗加齢医学会雑誌　12(3):369-373,2016.
  10. 新村　健：老化に挑む医学と医療。兵医大医会誌　40(1):27-30,2016.
  11. 新村　健：心臓老化のバイオロジーと臨床応用を見据えた心臓若返り法。 進歩する心臓研究－Tokyo Heart Journal　35(2):13-18, 2015.
  12. 新村　健：肥満と性差:性差が示唆する肥満の本質。血栓と循環　23(4):254-259,2015.
  13. 新村　健：サーチュイン遺伝子と心臓のアンチエイジング。アンチ･エイジング医学－日本抗加齢医学会雑誌　11(4):517-23,2015.
  14. 新村　健：Remote preconditioning。医学のあゆみ 253(6):525-526,2015.
  15. 新村　健：ミトコンドリア老化説再訪：ミトコンドリアタンパク折り畳み不全応答。医学のあゆみ 252(3):258-259,2015.