Department of Genetics

In Department of Genetics, we create and analyze model organisms and conduct genomic analysis of human diseases.
There are various model organisms, but in this course we use mice and Drosophila. Starting with the genome analysis of hereditary pancreatitis families, we are conducting research on pancreatic diseases by creating and analyzing several genetically modified mice, linking them with fields such as autophagy and cell death. In addition, through the analysis of the causative gene of the genetic disease Gorlin syndrome, we are attempting to explore the original role and evolutionary role of the causative gene. This type of research not only has the potential to answer the fundamental question of "why disease occurs," but also to contribute to a better understanding of genetic diseases and the development of new treatments.
We are also creating various genetically modified mice using the genome editing technology CRISPR/Cas9 system. We have performed various genetic modifications, such as gene knockout, knockin, overexpression, floxed mice, and single amino acid substitutions, to create disease model mice and develop their mechanisms and treatment methods.
It is known that many genetic and environmental factors increase the risk of developing cancer. The Kubota shock brought to light the social issue of asbestos health damage, but there are also malignant mesothelioma patients who have no history of asbestos exposure. For many years, we have conducted genetic analysis of malignant mesothelioma and the genetic factors behind it, and have found gene mutations that occur frequently in tumors and used them for diagnosis. We have also reported that the prognosis of patients with a large contribution from genetic factors is relatively good. We are currently conducting research into predicting prognosis from tumor mutation patterns, with the aim of using genetic analysis to lead to early detection and improved prognosis.