Department of Emergency Disaster and Critical Care Medicine

Departments of Clinical Sciences (Clinical Medicine)

(1) Research into emergency medicine

We are conducting research into the development and construction of a next-generation emergency medical system based on PHR/EHR, as well as retrospective cohort studies into excessive invasion due to trauma or disease, the epidemiology of sepsis and severe COVID-19, and basic research focusing on elucidating the mechanisms of biological reactions in sepsis and DIC and developing new treatments.

<Clinical Research>

Research on the development and construction of next-generation emergency medical systems based on PHR/EHR
・Emergency command system; development of dynamic matching system
・Bed command system; development of dynamic management system
・Development of a sepsis and shock prediction model
Epidemiological study of severe COVID19, retrospective cohort study
Research into initial treatment and intensive care management in severe trauma cases
Sepsis-related
・New therapeutic strategies for noradrenaline unresponsiveness
- Mechanism of NETs inhibition by anticoagulant therapy
・Organ damage caused by NETs
DIC epidemiology study
Shock and host defense mechanisms
Potential for early enteral nutrition and high protein administration in septic shock
Treatment methods for traumatic spinal injuries and pelvic fractures
Prevention and measures for serious postoperative complications

<Basic research>

Sepsis-related
・Relationship between sex hormones and lung disorders (clarification of neutrophil function)
・Potential for female hormone analogues to treat septic cardiomyopathy
- The potential of fudosteine to treat norepinephrine unresponsiveness in septic shock
・Regulation of hyperactivated neutrophil function during sepsis by female hormone analogues (Grant-in-Aid for Scientific Research)
Neutrophil NETs-related
・Research into the relationship between neutrophil apoptosis, NETs, and coagulation disorders in critically ill patients using specimens from sepsis patients (funded by a Grant-in-Aid for Scientific Research)
Hydrogen gas related
- Research into reducing organ damage with a focus on antioxidant effects
・Reduction of lung damage caused by hydrogen inhalation (Grant-in-Aid for Scientific Research)

(2) Research into disaster medicine

Research on the development and construction of next-generation emergency medical systems based on PHR/EHR
・Development of a model to predict the number of disaster victims who require medical assistance
・Development of virtual disaster training models using digital twin technology
Development of a high-quality information and communication system between disaster sites and leading medical facilities, modeled on emergency sites (pre-hospital first aid)
Development of a real-time image information communication system for building hospital-hospital collaboration, with the aim of also using it as a disaster communication system
Research based on real disaster medical experience and data:
In particular, in addition to providing on-site medical care during the JR Fukuchiyama Line derailment accident, our department also accepted 113 patients at the hospital, and has experience in triage and treatment of a large number of patients at the same time, as well as 2 hours and 40 minutes of detailed video footage, which has become valuable research material.In addition, we have many staff members who have responded to disaster medical care, and we are developing a high-quality information and communication system between disaster sites and leading medical facilities, modeled on emergency sites (pre-hospital first aid), which is a valuable research subject in research on the mental health of medical professionals.

Self-evaluation, inspection and future prospects

In clinical research, we have begun advanced joint research with SoftBank Corp. and HEMILLIONS Inc. on "Development and construction of a next-generation emergency medical system based on PHR/EHR collaboration" through medical digital transformation. This is a representative research project of our course that involves the public and private sectors, government, and academia.
We are conducting epidemiological and retrospective cohort studies of severe COVID-19 patients, many of whom have been admitted, and in basic research, we are tackling new research themes and advancing basic research into the roots of the disease. Although we are still in the early stages, we have discovered important new findings and obtained public funding. Going forward, we will promote an even more efficient research system that will enable research results to be directly applied to clinical practice.

Course Information

Professor: Junichi Hirata

Associate Professor: Taihei Yamada

Specially Appointed Associate Professor: Mariko Terashima, Atsushi Miyawaki (Concurrent Posts)

Clinical Associate Professor: Keisuke Kohama

FAX: 0798-45-6813

Course dedicated site: http://hyo-med-er.info/

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