生体分析化学分野

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前田初男　Hatsuo MAEDA

【原著論文・総説】

(28)	3′-O-(2-Nitrobenzenesulfonyl)fluorescein as a Fluorescent Probe for Hydrogen Polysulfides by Straightforward One-Step Deprotection Koji Tsukamoto, Hikaru Ohsawa, Ryosuke Nishiyama, Hatsuo Maeda Anal. Sens., 2023, 3 e202200084.

(27)

Estimation of muscle mass using creatinine/cystatin C ratio in Japanese community-dwelling older people
H. Kusunoki, Y. Tabara, S. Tsuji, Y. Wada, K. Tamaki, K. Nagai, M. Itoh, K. Sano, M. Amano, H. Maeda, H. Sugita, Y. Hasegawa, H. Kishimoto, S. Shimomura, M. Igase, K. Shinmura
J. Am. Med. Dir. Assoc., 2022, 23 (5), 902.e21-902.e31.

(26)

Relationships between cystatin C- and creatinine-based eGFR in Japanese rural community- dwelling older adults with sarcopenia
H. Kusunoki, S. Tsuji, T. Kusukawa, Y. Wada, K. Tamaki, K. Nagai, M. Itoh, K. Sano, M. Amano, H. Maeda, H. Sugita, Y. Hasegawa, H. Kishimoto, S. Shimomura, K. Shinmura
Clin. Exp. Nephrol., 2021, 25 231-239.

(25)	A fluorescent turn-on probe for Hg²⁺ with a high contrast designed by manipulating functional groups tethered to naphthalimide Y. Shinohara, K. Tsukamoto, H. Maeda J. Photochem. Photobio. A, Chem., 2019, 351 407-413.

(24)

Relationship between sarcopenia and the serum creatinine/cystatin C ratio in Japanese rural community‐dwelling older adults
H. Kusunoki, S. Tsuji, Y. Wada, M. Fukai, K. Nagai, M. Itoh, K. Sano, K. Tamaki1, Y. Ohta, M. Amano, H. Maeda, Y. Hasegawa, H. Kishimoto, S. Shimomura, H. Yoshikawa, K. Shinmura
JCSM Clinical Reports, 2018, 3 (1), e00057.

(23)

The relationship between dietary habits and frailty in rural japanese community-dwelling older adults: cross-sectional observation study using a brief self-administered dietary history questionnaire
K. Tamaki, H. Kusunoki, S. Tsuji, Y. Wada, K. Nagai, M. Itoh, K. Sano, M. Amano, H. Maeda, Y. Hasegawa, H. Kishimoto, S. Shimomura, K. Shinmura
Nutrients, 2018, 10 (12), 1982.

(22)	A naphthalimide-based Cd²⁺ fluorescent probe with carbamoylmethyl groups working as chelators and PET-promoters under neutral conditions K. Tsukamoto, S. Shimabukuro, M. Mabuchi, H. Maeda Chem. Eur. J., 2016, 22 (25), 8579-8585.

(21)	Establishment of background color to discriminate among tablets: sharper and more feasible with color-weak simulation as access to safe medication M. Ishizaki, H. Maeda, I. Okamoto Yakugaku Zasshi, 2014, 134 (10), 1081-1092.

(20)	An anthracene-based Cd²⁺ fluorescent chemosensor with a 4,7-bis(2-hydroxyethyl)-9-hydroxy-1,4,7-triazanonyl group as a highly selective chelator to Cd²⁺ over Zn²⁺ A. Okano, K. Tsukamoto, S. Kosaka, H. Maeda, S. Oishi, T. Tanaka, N. Fujii, H. Ohno Tetrahedoron Lett., 2013, 54 (45), 5791-5973.

(19)	Establishment of the background color to make discrimination of domestic ethical tablets sharper and more feasible based on the analysis of their color distributions M. Ishizaki, H. Maeda, I. Okamoto Yakugaku Zasshi, 2012, 132 (4), 507-515.

(18)	A coumarin-based fluorescent probe for Hg²⁺ and Ag⁺ with an N′-acetylthioureido group as a fluorescence switch K. Tsukamoto, Y. Shinohara, S. Iwasaki, H. Maeda Chem. Commun., 2011, 47, 5073-5075.

(17)	Synthesis of fused and linked bicyclic nitrogen heterocycles by palladium-catalyzed domino cyclization of propargyl bromides A. Okano, K. Tsukamoto, S. Kosaka, H. Maeda, S. Oishi, T. Tanaka, N. Fujii, H. Ohno Chem. Eur. J., 2010, 16, 8410-8418.

(16)	Molecular display technology using yeast－Arming technology－ S. SHIBASAKI, H. MAEDA, M. UEDA Anal. Sci., 2009, 25 (1), 41-49.

(15)	Which are you watching, an individual ROS or total oxidative stress? H. Maeda Ann. N. Y. Acad. Sci., 2008, 1130 149-156.

(14)	Direct construction of bicyclic hetrocycles by palladium-catalyzed domino cyclization of propagyl bromides H. Ohno, A. Okano, S. Kosaka, K. Tsukamoto, M. Ohta, K. Ishihara, H. Maeda, T. Tanaka, N. Fujii Org. Lett., 2008, 10, 1171-1174.

(13)	蛍光プローブで見たいものだけを見る－活性酸素種，酵素活性およびセレノプロテインを計る－前田初男蛋白質核酸酵素（増刊号「ケミカルバイオロジー」），2007, 52 (13), 1524-1528.

(12)	Design of a practical fluorescent probe for superoxide based on protection-deprotection chemistry of fluoresceins with benzenesulfonyl protecting groups H. Maeda, K. Yamamoto, I. Kohno, L. Hafsi, N. Itoh, S. Nakagawa, N. Kanagawa, K. Suzuki, and T. Uno. Chem. Eur. J., 2007, 13, 1946-1954.

(11)	3'-(2,4-Dinitrobenzenesulfonyl)-2',7'-dimethylfluorescein as a fuorescent probe for selenols H. Maeda, K. Katayama, H. Matsuno, and T. Uno Angew. Chem. Int. Ed., 2006, 45, 1810-1813.

(10)	Omics vs. Chemical Biology 前田初男生物工学，2006, 84, 169.

(9)	保護／脱保護化学に基づく蛍光プローブの設計開発前田初男生物工学，2006, 84, 184-187.

(8)	必須微量元素セレンをはかる：セレノールの可視化計測前田初男海洋化学研究，2006, 19, 34-40.

(7)	2,4-Dinitrobenzenesulfonyl fluoresceins as fluorescent alternatives to Ellman’s reagent in thiol-quantification enzyme assays H. Maeda, H. Matsuno, M. Ushida, K. Katayama, K. Saeki and N. Itoh Angew. Chem. Int. Ed., 2005, 44, 2922-2925.

(6)	Important role of the 3-mercaptopropionamide moiety in glutathione: Promoting effect on decomposition of the adduct of glutathione with the oxoammonium ion of TEMPO H. Maeda, H.-Y. Wu, Y. Yamauchi and H. Ohmori J. Org. Chem., 2005, 70, 8338-8343.

(5)	A design of fluorescent probes for superoxide based on a nonredox mechanism H. Maeda, K. Yamamoto, Y. Nomura, I. Kohno, L. Hafsi, N. Ueda, S. Yoshida, M. Fukuda, Y. Fukuyasu, Y. Yamauchi and N. Itoh J. Am. Chem. Soc., 2005, 127, 68-69.

(4)	化学的脱保護反応を発蛍光機構とする蛍光プローブの設計開発前田初男和光純薬時報，2005, 73, 2-4.

(3)	High performance liquid chromatography equipped with a cathodic detector and column-switching device as a high-throughput method for a phosphatase assay with p-nitrophenylphosphate Y. Yamauchi, M. Ido and H. Maeda J. Chromatogr. A, 2005, 1066, 127-132.

(2)	Fluorescent probes for hydrogen peroxide based on a non-oxidative mechanism H. Maeda, Y. Fukuyasu, S. Yoshida, M. Fukuda, K. Saeki, H. Matsuno, Y. Yamauchi, K. Yoshida, K. Hirata and K. Miyamoto Angew. Chem. Int. Ed., 2004, 43, 2389-2391.

(1)	High performance liquid chromatography with an electrochemical detector in the cathodic mode as a tool for the determination of p-nitro-phenol and assay of acid phosphatase in urine samples Y. Yamauchi, M. Ido, M. Ohta and H. Maeda Chem. Pharm. Bull., 2004, 52, 552-555.

【著書】

(3)	ベーシック薬学教科書シリーズ　分析科学（第３版）萩中淳［編］，片岡洋行，小林典裕，田和理市，萩中淳，前田初男［著］，化学同人，2019．

(2)	第４章　酸・塩基平衡，中和滴定，非水滴定パートナー分析化学Ⅰ（改訂第３版），萩中淳，熊田均，山口政俊［編］，南光堂、2017，pp 35-65．

(1)	SBO 10，17 スタンダード薬学シリーズ２・物理系薬学Ⅱ．化学物質の分析　第２版，日本薬学会編，東京化学同人，2022，pp 61-71，150-164.

【特許】

(2)	特願 2003-273659 (2003)，特開 2005-47898 (2005). 「スルホン酸エステルおよびそれを用いた蛍光プローブ」出願人：財団法人大阪産業振興機構発明者：前田初男，平田收正，宮本一久

(1)	特願 2003-273660 (2003)，特開 2005-47891 (2005). 「スルホン酸エステルおよびそれを用いた蛍光プローブ」出願人：財団法人大阪産業振興機構発明者：前田初男，伊藤徳夫

塚本効司　Koji TSUKAMOTO

【原著論文】

(9)	A fluorescent turn-on probe for Hg²⁺ with a high contrast designed by manipulating functional groups tethered to naphthalimide Y. Shinohara, K. Tsukamoto, H. Maeda J. Photochem. Photobio. A, Chem., 2019, 351 407-413.

(8)	A naphthalimide-based Cd²⁺ fluorescent probe with carbamoylmethyl groups working as chelators and PET-promoters under neutral conditions K. Tsukamoto, S. Shimabukuro, M. Mabuchi, H. Maeda Chem. Eur. J., 2016, 22 (25), 8579-8585.

(7)	An anthracene-based Cd²⁺ fluorescent chemosensor with a 4,7-bis(2-hydroxyethyl)-9-hydroxy-1,4,7-triazanonyl group as a highly selective chelator to Cd²⁺ over Zn²⁺ A. Okano, K. Tsukamoto, S. Kosaka, H. Maeda, S. Oishi, T. Tanaka, N. Fujii, H. Ohno Tetrahedoron Lett., 2013, 54 (45), 5791-5973.

(6)	A coumarin-based fluorescent probe for Hg²⁺ and Ag⁺ with an N′-acetylthioureido group as a fluorescence switch K. Tsukamoto, Y. Shinohara, S. Iwasaki, H. Maeda Chem. Commun., 2011, 47, 5073-5075.

(5)	Synthesis of fused and linked bicyclic nitrogen heterocycles by palladium-catalyzed domino cyclization of propargyl bromides A. Okano, K. Tsukamoto, S. Kosaka, H. Maeda, S. Oishi, T. Tanaka, N. Fujii, H. Ohno Chem. Eur. J., 2010, 16, 8410-8418.

(4)	Direct construction of bicyclic hetrocycles by palladium-catalyzed domino cyclization of propagyl bromides H. Ohno, A. Okano, S. Kosaka, K. Tsukamoto, M. Ohta, K. Ishihara, H. Maeda, T. Tanaka, N. Fujii Org. Lett., 2008, 10, 1171-1174.

(3)	Direct construction of bicyclic hetrocycles by palladium-catalyzed domino cyclization of propagyl bromides H. Ohno, A. Okano, S. Kosaka, K. Tsukamoto, M. Ohta, K. Ishihara, H. Maeda, T. Tanaka, N. Fujii Org. Lett., 2008, 10, 1171-1174.

(2)	Calix[6]arene-based template for X-ray crystallographic analysis of template-assembled synthetic proteins K. Tsukamoto, H. Ohishi, N. Maezaki, T. Tanaka, T. Ishida ChemBioChem, 2006, 7, 1559-1562.

(1)	Self-assembled octameric cage constructed by the potassium salt of p-tert-butylcalix[6]arene p-bromophenylalanine derivative in the solid state K. Tsukamoto, H. Ohishi, Y. Hiyama, N. Maezaki, T. Tanaka, T. Ishida Chem. Commun., 2006, 3606-3608.

石崎真紀子　Makiko ISHIZAKI

【原著論文】

(3)	Dark Gray Background Helps Cataract Patients Discriminate Each Ethical Tablet to Work as a UD for Safer andSecurerMedication M. Ishizaki, H. Maeda, I. Okamoto The Proceedings of the 4th International Conference for Universal Design in FUKUOKA 2012, 2014, 375-384.

(2)	Establishment of background color to discriminate among tablets: sharper and more feasible with color-weak simulation as access to safe medication M. Ishizaki, H. Maeda, I. Okamoto Yakugaku Zasshi, 2014, 134 (10), 1081-1092.

(1)	Establishment of the background color to make discrimination of domestic ethical tablets sharper and more feasible based on the analysis of their color distributions M. Ishizaki, H. Maeda, I. Okamoto Yakugaku Zasshi, 2012, 132 (4), 507-515.

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