Medicinal Chemistry (Chemical Biology)

In medicinal chemistry, we aim to create new pharmaceutical drugs by synthesizing and developing biologically active substances, such as seed compounds that are effective against specific diseases, into safer and more effective compounds. We are utilizing our drug discovery experience in medicinal chemistry and pharmacology in the pharmaceutical company (for example, Romidepsin). In our laboratory, we also conduct research in Chemical Biology, utilizing chemical compounds (the power of chemistry) to elucidate biological functions, because one of the goals of chemical biology is drug discovery. And we have developed an affinity resin called AquaFirmusTMwhich is hydrophilic and chemically stable, to identify the target proteins of the bioactive compounds, aiming to elucidate mechanisms and accelerate drug discovery. This resin has also been utilized by pharmaceutical companies, and we have established a venture. To date, we have collaborated with companies or other universities, concerning target protein identification for pharmaceutical development compounds with unknown mechanisms, and have engaged in drug discovery research for the treatment of prostate cancer, allergies, and bladder cancer. Currently, we have identified the targets of a screening hit compound effective against malaria. We are developing new compounds for malaria-resistant strains while examining oral bioavailability, cardiotoxicity, and metabolic stability. We are conducting research to contribute to the health of people around the world, with support from organizations such as AMED (Japan Agency for Medical Research and Development), GHIT (Global Health Innovative Technology), and MMV (Medicines for Malaria Venture).