兵庫医科大学免疫学講座 トップページ

2009年

Yoshimoto T, Yasuda K, Tanaka H, Nakahira M, Imai Y, Fujimori Y, and Nakanishi K.
Basophils contribute to Th2/IgE response in vivo via IL-4 production and presentation of peptide-MHC class II complexes to CD4⁺ T cells.
Nat. Immunol. 10:706-12, 2009.

Harada M, Obara K, Hirota T, Yoshimoto T, Hitomi Y, Sakashita M, Doi S, Miyatake A, Fujita K, Enomoto T, Taniguchi M, Higashi N, Fukutomi Y, Nakanishi K, Nakamura Y, Tamari M.
A functional polymorphism in IL-18 is associated with severity of bronchial asthma.
Am. J Respir. Crit. Care Med. 180:1048-55, 2009.

2008年

Kosaka H, Yoshimoto T, Yoshimoto T, Fujimoto J, and Nakanishi K.
Interferon-γ is a therapeutic target molecule for prevention of postoperative adhesion formation.
Nat. Med. 14:437-41, 2008.

Kondo Y, Yoshimoto T, Yasuda K, Futatsugi-Yumikura S, Morimoto, M, Hayashi N, Hoshino T, Fujimoto J, and Nakanishi K.
Administration of IL-33 induces airway hyperresponsiveness and goblet cell hyperplasia in the lungs in the absence of adaptive immune system.
Int. Immunol, 20:791-800, 2008.

Sakishita M, Yoshimoto T, Hirota T, Harada M, Ohkubo K, Osawa Y, Fujieda S, Nakamura Y, Yasuda K, Nakanishi K, and Tamari M.
Association of IL-33 level and IL-33 genetic variant with Japanese cedar pollinosis.
Clin. Exp. Allergy. 38:1875-81, 2008.

Seki, E., Kondo, Y., Iimuro, Y., Naka, T., Son, G., Kishimoto, T., Fujimoto, J., Tsutsui, H. and Nakanishi, K.
Demonstration of cooperative contribution of MET- and EGFR-mediated STAT3 phosphorylation to liver regeneration by exogenous suppressor of cytokine signalings.
J. Hepatol., 48: 237-245. 2008.

2007年

Hayashi, N., Yoshimoto, T., Izuhara, K., Matsui, K., Tanaka, T., Nakanishi, K.
T helper 1 cells stimulated with ovalbumin and IL-18 induce airway hyperresponsiveness and lung fibrosis by IFN-γ and IL-13 production.
Proc. Natl. Acad. Sci. USA. 104: 14765-14770. 2007.

Yoshimoto, T., Yoshimoto, T., Yasuda, K., Mizuguchi, J. and Nakanishi, K.
IL-27 Suppresses Th2 cell development and Th2 cytokines production from polarized Th2 Cells: a novel therapeutic way for Th2-mediated allergic inflammation.
J. Immunol. 179: 4415-4423. 2007.

Fujibayashi, Y., Fujimori, Y., Kasumoto, I., Kai, S., Hara, H., Okamura, H., Tsutsui, H., Ogawa, H. and Nakanishi, K.
Interleukin-18 regulates T helper 1 or 2 immune responses of human cord blood CD4⁺ Vα24⁺Vβ11⁺ natural killer T cells.
Int. J. Mol. Med. 20: 241-245. 2007.

Iimuro, Y., Seki, E., Son, G., Tsutsui, H., Nakanishi, K. and Fujimoto, J.
Role of innate immune response in liver regeneration. J.
Gastroenterol. Hepatol., 22: S57-58. 2007.

Arizono, N., Nakanishi, K., Horii, T. and Tanabe, K.
Progress in the molecular biology of malaria and the immunology of nematode infections.
Trends in Parasitology, 23: 175-181. 2007.

Sawaki, J., Tsutsui, H., Hayashi, N., Yasuda, K., Akira, S., Tanizawa, T. and Nakanishi, K.
Type 1 cytokine/chemokine production by mouse NK cells following activation of their TLR/MyD88-mediated pathways.
Int. Immunol.19: 311-320. 2007.

2006年

Omoto, Y., Tokime, K., Yamanaka, K., Habe, K., Morioka, T., Kurokawa, I., Tsutsui, H., Yamanishi, K., Nakanishi, K. and Mizutani, H.
Human Mast Cell Chymase Cleaves Pro-IL-18 and Generates a Novel and Biologically Active IL-18 Fragment.
J. Immunol. 177: 8315-8319. 2006.

Umeda, K., Noro, Y., Murakami, T., Tokime, K., Sugisaki, H., Yamanaka, K., Kurokawa, I., Kuno, K., Tsutsui, H., Nakanishi, K. and Mizutani, H.
A novel acoustic evaluation system of scratching in mouse dermatitis: Rapid and specific detection of invisibly rapid scratch in an atopic dermatitis model mouse.
Life Sci. 79: 2144-2150. 2006.

Terada, M., Tsutsui, H., Imai, Y., Yasuda, K., Mizutani, H., Yamanishi, K., Kubo, M., Matsui, K., Sano, H. and Nakanishi, K.
Contribution of interleukin-18 to atopic dermatitis-like skin inflammation induced by Staphylococcus aureus product in mice.
Proc. Natl. Acad. Sci. USA. 103: 8816-8821. 2006.

Ishikawa, Y., Yoshimoto, T. and Nakanishi, K.
Contribution of IL-18-induced innate T cell activation to airway inflammation with mucus hypersecretion and airway hyperresponsiveness.
Int. Immunol. 18: 847-855. 2006.

Murakami, T., Yamanaka, K., Tokime, K., Kurokawa, I., Tsutsui, H., Nakanishi, K. and Mizutani, H.
Topical suplatast tosilate (IPD) ameliorates Th2 cytokine-mediated dermatitis in caspase-1 transgenic mice by downregulating interleukin-4 and interleukin-5. Br.
J. Dermatol. 155: 27-32. 2006.

Inokuchi, T., Moriwaki, Y., Tsutsui, H., Yamamoto, A., Takahashi, S., Tsutsumi, Z., Ka ,T., Nakanishi, K., and Yamamoto, T.
Plasma interleukin (IL)-18 (Interferon-γ inducing factor) and other inflammatory cytokines in patients with gouty arthritis and monosodium urate monohydrate crystal-induced secretion of IL-18.
Cytokine. 33: 21-27. 2006.

2005年

Hamasaki, T., Hashiguchi, S., Ito, Y., Kato, Z., Nakanishi, K., Nakashima, T. and Sugimura, K.
Human anti-human IL-18 antibody recognizing the IL-18-binding site 3 with IL-18 signaling blocking activity.
J. Biochem. 138:433-442. 2005.

Sasaki, Y., Yoshimoto, T., Maruyama, H., Tegoshi, T., Ohta, N., Arizono, N. and Nakanishi. K.
IL-18 with IL-2 protects against Strongyloides venezuelensis infection by activating mucosal mast cell-dependent type 2 innate immunity.
J. Exp. Med. 202: 607-616. 2005.

Kyo, F., Futani, H., Matsui, K., Terada, M., Adachi, K., Nagata, K., Sano, H., Tateishi, H., Tsutsui, H. and Nakanishi, K.
Endogenous IL-6 but not TNF-α contributes to the development of TLR4/MyD88-mediated acute arthritis in mice.
Arthritis & Rheum. 52: 2530-2540. 2005.

Fujii, H., Seki, S., Kobayashi, S., Kitada, T., Kawakita, N., Adachi, K., Tsutsui, H., Nakanishi, K., Fujiwara, H., Ikarashi, Y., Taniguchi, M., Mitchell, K., Ikemoto, M., Nakajima, Y., Arakawa, T. and Kaneda, K.
A murine model of NKT cell-mediated liver injury induced by alpha-galactosylceramide/ d-galactosamine.
Virchows Archiv. 446: 663-673. 2005.

Yamaguchi, N., Fujimori, Y., Fujibayashi, Y., Kasumoto, I., Okamura, H, Nakanishi, K. and Hara, H.
Interferon-γ production by human cord blood monocyte-derived dendritic cells.
Ann. Hematol., 84:423-428. 2005.

Suzuki, T., Nakanishi, K., Tsutsui, H., Iwai, H., Akira, S., Inohara, N., Chamaillard, M., Nunez, G. and Sasakawa, C.
A novel caspase-1/toll-like receptor 4-independent pathway of cell death induced by cytosolic Shigella in infected macrophages.
J. Biol. Chem., 280:14042-14050. 2005.

Seki, E., Tsutsui, H., Iimuro, Y., Naka, T., Son, G., Akira, S., Kishimoto, T., Nakanishi, K. and Fujimoto, J.
Contribution of Toll-like receptor/myeloid differentiation factor 88 signaling to murine liver regeneration.
Hepatology, 41:443-450. 2005.

Oh, K., Iimuro, Y., Takeuchi, M., Kaneda, Y., Iwasaki, T., Terada, N., Matsumoto, T., Nakanishi, K. and Fujimoto, J.
Ameliorating effect of hepatocyte growth factor on inflammatory bowel disease in a murine model. Am. J. Physiol.
Gastrointest Liver Physiol., 288(4):G729-735. 2005.