論文（2000年-2004年）
2004年
Tsutsui, H., Yoshimoto, T., Hayashi, N., Mizutani, H. and Nakanishi, K.
Induction of allergic inflammation by IL-18 in experimental animal models.
Immunological Review, 202:115-138. 2004
Hata, H., Yoshimoto, T., Hayashi, N., Hada, T.and Nakanishi, K.
IL-18 together with anti-CD3 antibody induces human Th1 cells to produce Th1- and Th2-cytokines and IL-8.
Int Immunol. 16:1733-1739. 2004.
Itoi, H., Fujimori, Y., Tsutsui, H., Matsui, K., Sugihara, A., Terada, N., Hada, T., Kakishita, E., Okamura, H., Hara, H. and Nakanishi, K.
Involvement of interleukin-18 in acute graft-versus-host disease in mice.
Transplantation, 78:1245-1250. 2004.
Yamamoto, M., Yaginuma, K., Tsutsui, H., Sagara1,J., Guan1, X., Seki, E., Yasuda, K., Yamamoto, M. Akira, S., Nakanishi, K., Noda, T., and Taniguchi1, S.
ASC is essential for LPS-induced activation of procaspase-1independently of TLR-associated signal adaptor molecules.
Genes Cells., 9:1055-1067.2004.
Saiki, O., Uda, H., Nishimoto, N., Miwa, T., Mima, T., Ogawara, T., Azuma, N., Katada, Y., Sawaki, J., Tsutsui, H., Matsui, K., Maeda, A. and Nakanishi, K.
Adult Still's disease reflects a Th2 rather than a Th1 cytokine profile.
Clin Immunol., 112:120-125. 2004.
Itoi, H., Fujimori, Y., Tsutsui, H., Matsui, K., Hada, T., Kakishita, E., Okamura, H., Hara, H. and Nakanishi, K.
Differential upregulation of interleukin-18 receptor alpha chain between CD4(+) and CD8(+) T cells during acute Graft-Versus-Host Disease in mice.
J. Interferon Cytokine Res., 24: 291-296. 2004.
Adachi, K., Tsutsui, H., Seki, E., Nakano, H., Takeda, K., Okumura, K., Van Kaer L. and Nakanishi, K.
Contribution of CD1d-unrestricted hepatic DX5+ NKT cells to liver injury in Plasmodium berghei-parasitized erythrocyte-injected mice.
Int. Immunol.,16: 787-798. 2004.
Sugimoto, T., Ishikawa, Y., Yoshimoto, T., Hayashi, N., Fujimoto, J. and Nakanishi, K.
Interleukin 18 acts on memory T helper cells type 1 to induce airway inflammation and hyperresponsiveness in a naive host mouse.
J. Exp. Med.,199:535-545. 2004.
Li Y, Ishii K, Hisaeda H, Hamano S, Zhang M, Nakanishi K, Yoshimoto T, Hemmi H, Takeda K, Akira S, Iwakura Y, Himeno K.
IL-18 gene therapy develops Th1-type immune responses in Leishmania major-infected BALB/c mice: is the effect mediated by the CpG signaling TLR9?
Gene Ther. 11: 941-948. 2004.
Kojima, S., Nagamine, Y., Hayano, M., Looareesuwan, S. and Nakanishi, K.
A potential role of interleukin 18 in severe falciparum malaria.
Acta Trop., 89:279-284. 2004.
Tsuji, N.M., Tsutsui, H., Seki, E., Kuida, K., Okamura, H., Nakanishi, K. and Flavell, R.A.
Roles of caspase-1 in Listeria infection in mice.
Int. Immunol., 16:335-343. 2004.
Fujimoto, M., Tsutsui, H., Xinshou, O., Tokumoto, M., Watanabe, D., Shima, Y., Yoshimoto, T., Hirakata, H., Kawase, I., Nakanishi, K., Kishimoto, T. and Naka, T.
Inadequate induction of suppressor of cytokine signaling-1 causes systemic autoimmune diseases.
Int. Immunol. 16:303-314. 2004.
2003年
Matsui, K., Tsutsui, H. and Nakanishi, K.
Pathophysiological roles for IL-18 in inflammatory arthritis.
Expert Opinion on Therapeutic Targets, 7:701-724. 2003.
Nagamine, Y., Hayano, M., Kashiwamura, S-I., Okamura, H., Nakanishi, K., Krudsod, S., Wilairatana, P., Looareesuwan, S. and Kojima, S.
Involvement of interleukin-18 in severe Plasmodium falciparum malaria. Trans. R.
Soc. Trop. Med. Hyg., 97:236-241. 2003.
Kaizu, M., Ami, Y., Nakasone, T., Sasaki, Y., Izumi, Y., Sato, H., Takahashi, E., Sakai, K., Shinohara, K., Nakanishi, K. and Honda, M.
Higher levels of IL-18 circulate during primary infection of monkeys with a pathogenic SHIV than with a nonpahogenic SHIV.
Virology, 313:8-12. 2003.
Tsutsui, H., Yoshimoto, T., Okamura, H. and Nakanishi, K.
Interlukin-18.
In: Encyclopedia of Hormones, ( HL. Henry and AW. Norman, eds.), Elsevier Science, 493-500. 2003.
Tsutsui, H., Adachi, K., Seki, E. and Nakanishi, K.
Cytokine-induced inflammatory liver injury.
Current Molecular Medicine, 3:545-559. 2003.
Ogushi, I., Iimuro, Y., Seki, E., Sonm G., Hirano, T., Hada, T., Tsutsui, H., Nakanishi, K., Morishita, R., Kaneda, Y. and Fujimoto, J.
Nuclear factor κB decoy oligodeoxynucleotides prevent endotoxin-induced fatal liver failure in a murine model.
Hepatology 38:335-344. 2003.
Tsutsui, H., Yoshimoto, T., Okamura, H., Akira, S. and Nakanishi, K.
IL-18 and IL-18 Receptor Knockout Mouse.
In: Cytokine Knockouts (Giamila Fantuzzi, eds), Human Press, Totowa, New Jersey, 303-322. 2003.
Okamura, H., Lotze, M. T., Tsutsui, H., Kashiwamura, S-I., Ueda, H., Yoshimoto, T. and Nakanishi , K.
Interleukin-18. [IL-1F4]
In: The cytokine handbook (4th edition), (Thomson, A. W. and Lotze, M. T., eds), Elsevier Science Ltd., London, 709-733. 2003.
Nakano, H., Tsutsui, H., Terada, M., Yasuda, K., Matsui, K., Yumikura-Futatsugi, S., Yamanaka, K., Mizutani, H. Yamamura, T. and Nakanishi, K.
Persistent secretion of IL-18 in the skin contributes to systemic IgE response in mice.
Int. Immunol. 15:611-621. 2003.
Yoshimoto, T., Min, B., Sugimoto, T., Hayashi, N., Ishikawa, Y., Sasaki, Y., Hata, H., Takeda, K., Okumura, K., Kaer, L. V., Paul, W. E. and Nakanishi, K.
Non-redundant roles for CD1d-restricted NKT cells and conventional CD4+ T cells in the induction of IgE antibodies in response to IL-18 treatment of mice.
J. Exp. Med. 197:997-1005. 2003.
Suzuki, N., Chen, N-J., Millar, D. G. , Suzuki, S., Horacek, T., Hara, H., Bouchard, D., Nakanishi, K., Penninger, J. M., Ohashi, P. S. and Yeh, W-C.
IRAK-4 is essential for Interleukin-18-mediated natural killer and T helper cell type 1 responses. J.
Immunol. 170:4031-4035. 2003.
Hayashi, H., Inoue, Y., Tsutsui, H., Okamura, H., Nakanishi, K. and Onozaki, K.
TGF beta down-regulates IFN-γ production in IL-18 treated NK cell line LNK5E6.
Biochem. Biophys. Res. Commun. 300:980-985. 2003.
2002年
Nakagawa, R., Naka, T., Tsutsui, H., Fujimoto, M., Kimura, A., Abe. T., Seki, E., Sato, S., Takeuchi, O., Takeda, K., Akira, S., Yamanishi, K., Kawase, I., Nakanishi, K. and Kishimoto, T.
SOCS-1 participates in negative regulation of LPS responses.
Immunity. 17:677-687. 2002.
Fujimoto, M., Tsutsui, H., Yumikura-Futatsugi, S., Ueda, H., Xingshou, O., Abe, T., Kawase, I., Nakanishi, K., Kishimoto, T. and Naka, T.
A regulatory role for SOCS-1 in T helper polarization in vivo.
Int. Immunol. 14:1343-1350. 2002.
Nakamoto, Y., Kaneko, S., Fan, H., Momoi, T., Tsutsui, H., Nakanishi, K., Kobayashi, K. and Suda, T.
Prevention of hepatocellular carcinoma development associated with chronic hepatitis by anti-fas ligand antibody therapy.
J. Exp. Med. 196:1105-1111. 2002.
Seki, E., Tsutsui, H., Tsuji, M. N., Hayashi, N., Adachi, K., Nakano, H., Futatsugi-Yumikura, S., Takeuchi, O., Hoshino, K., Akira, S., Fujimoto, J. and Nakanishi, K.
Critical roles of MD88-dependent proinflammatory cytokine release in early phase clearance of Listeria monocytogenes.
J. Immunol. 169:3863-3868, 2002.
Fujimori, Y., Yoshimoto, T., Matsui, K., Tsutsui, H., Okamoto, T., Kashiwamura, S., Hada, T., Okamura, H., Kakishita, E., Hara, H. and Nakanishi, K.
Short Communication: Increased expression of Interleukin-18 receptor on T lymphocytes in patients with acute graft-versus-host disease after allogeneic bone marrow transplantation.
J. Interferon Cytokine Res. 22:751-754, 2002.
Konishi, H., Tsutsui, H., Murakami, T., Nakano, H., Yamanaka, K., Yumikura-Futatsugi, S., Tanaka, M., Iwakura, Y., Fuchs, E. V., Okamura, H., Suzuki, N., Nakanishi, K. and Mizutani, H.
IL-18 contributes to the spontaneous development of atopic dermatitis-like inflammatory skin lesion independently of IgE/stat6 under specific pathogen-free conditions.
Proc. Natl. Acad. Sci. USA. 99:11340-11345, 2002.
Ben-Sasson, S. Z., Zukovsky, I., Biton, A., Vogel, R., Foucras, G., Hayashi, N., Paul, W. E.
Generation and characterization of memory CD4 T cells.
Adv. Exp. Med. Biol. 512:129-134. 2002.
Hayashi, N., Liu, D., Min, B., Ben-Sasson, S. Z., Paul, W. E.
Antigen challenge leads to in vivo activation and elimination of highly polarized TH1 memory T cells.
Proc. Natl. Acad. Sci. USA. 99:6187-6191. 2002.
Futani, H., Okayama, A., Matsui, K., Kashiwamura, S-I., Sasaki, T., Hada, T., Nakanishi, K., Tateishi, H., Maruo, S. and Okamura, H.
Relation between Interleukin-18 and PGE2 in synovial fluid of osteoarthritis: A potential therapeutic target of cartilage degradation.
J. Immunother. 25:61-64, 2002.
Iwasaki, T., Yamashita, K., Tsujimura, T., Kashiwamura, S., Tsutsui, H., Kaisho, T., Sugihara, A., Yamada, N., Mukai, M., Yoneda, T., Okumura, H., Akedo, H. and Terada, N.
Interluekin-18 inhibits osteolytic bone metastasis by human lung cancer cells possibly through suppression of oseoclastic bone-resorption in nude mice.
J. Immunotherapy, 25:s52-s60, 2002.
Kimura-Shimmyo, A., Kashiwamura, S-I., Ueda, H., Ikeda, T., Kanno, S., Akira, S., Nakanishi, K., Mimura, O. and Okamura, H.
Cytokine-induced injury of the lacrimal and salivary glands.
J. Immunother. 25:42-51, 2002.
Shimoda, K., Tsutsui, H., Aoki, K., Kato, K., Matsuda, T., Numata, A., Takase, K., Yamamoto, T., Nukina, H., Hoshino, T., Asano, Y., Gondo, H., Okamura, T., Okamura, S., Nakayama, K., Nakanishi, K., Niho, Y., and Harada, M.
Partial impairment of IL-12 and IL-18 signaling in Tyk2-deficient mice.
Blood. 99:2094-2099, 2002.
2001年
Adachi, K., Tsutsui, H., Kashiwamura, S-I., Seki, E., Nakano, H., Takeuchi, O., Takeda, K., Okumura, K., Kaer, L.V., Okamura, H., Akira, S. and Nakanishi, K.
Plasmodium berghei infection in mice induces liver injury by an IL-12- and Toll-like receptor/myeloid differentiation factor 88-dependent mechanism.
J. Immunol. 167:5928-5934, 2001.
Tanaka, T., Tsutsui, H., Yoshimoto, T., Kotani, M., Matsumoto, M., Fujita, A., Wang, W., Higa, S., Kishimoto, T., Nakanishi, K. and Suemura, M.
Interleukin-18 is elevated in the sera from patients with atopic dermatitis and from atopic dermatitis model mice, NC/Nga.
Int. Arch. Allergy Immunol. 125:236-40, 2001.
Naka, T., Tsutsui, H., Fujimoto, M., Kawazoe, Y., Kohzaki, H., Morita, Y., Nakagawa, R., Narazaki, M., Adachi, K., Yoshimoto, T., Nakanishi, K. and Kishimoto, T.
SOCS (Suppressor Of Cytokine Signaling)-/SSI (STAT induced STAT Inhibitor)-1-defficient hepatic NKT cells participate in severe hepatitis through dysregulated cross-talk inhibition of IFN-γ and IL-4 signaling in vivo.
Immunity. 14:535-545, 2001.
Itoi, H., Fujimori, Y., Tsutsui, H., Matsui, K., Futatsugi, S., Okamura, H., Hara, H., Hada, T., Kakishita, E. and Nakanishi, K.
Fas ligand-induced caspase-1-dependent accumulation of interleukin (IL)-18 in mice with acute graft-versus-host disease.
Blood. 98:235-237, 2001.
Seki, E., Tsutsui, H., Nakano, H., Tsuji, N.M., Hoshino, K., Adachi, O., Adachi, K., Futatsugi, S., Kuida, K., Takeuchi, O., Okamura, H., Fujimoto, J., Akira, S. and Nakanishi, K.
Lipopolysaccharide-induced IL-18 selection from murine Kupffer cells independently of Myeloid differentiation factor 88 that is critically involved in induction of production of IL-12 and IL-1β.
J. Immunol. 166:2651-2657, 2001.
Yoshimoto, T., Tsutsui, H., Okamura, H. and Nakanishi, K.
Measurement of human and mouse Interleukin 18.
In: Current Protocol in Immunology, (Coligan, J.E., Kruisbeek, A.M., Margulies, D.H., Shevach, E.M. and Strober, W. eds.), John Wiley & Sons, Inc., New York, 6.26.1- 6.26.12. 2001.
Nakanishi, K., Yoshimoto, T., Kashiwamura, S-I., Tsutsui, H. and Okamura, H.
Interleukin-18.
In: Cytokine Therapeuticx in Infectious Diseases, (Holland, S.M. eds.), Lippincott Williams & Wilkins, Philadelphia. 119-144. 2001.
Nakanishi, K., Yoshimoto, T., Tsutsui, H.and Okamura, H.
Interleukin-18 is a unique cytokine that stimulates both Th1 and Th2 responses depending on its cytokine milieu.
Cytokine & Growth Factor Reviews, 12:53-72. 2001.
Nakanishi, K., Yoshimoto, T., Tsutsui, H.and Okamura, H.
Interleukin-18 regulates both Th1 and Th2 responces.
Annu. Rev. Immunol. 19: 423-474. 2001.
Nakanishi, K.
Innate and acquired activation pathways in T cells.
Nat. Immunol., 2:140-142. 2001.
2000年
Chikano, S., Sawada, K., Shimoyama, T., Kashiwamura, S-I., Sugihara, A., Sekikawa, K., Terada, N., Nakanishi, K. and Okamura, H.
IL-18 and IL-12 induce intestinal inflammation and fatty liver in mice in an IFN-γ dependent manner.
Gut. 47:779-786, 2000.
Yoshimoto, T., Mizutani, H., Tsutsui, H., Noben-Trauth, N., Yamanaka, K-I., Tanaka, M., Izumi, S., Okamura, H., Paul, W.E. and Nakanishi, K.
IL-18 induction of IgE: dependence on CD4+T cells, IL-4 and STAT6.
Nat. Immunol. 1:132-137, 2000.
Yamanaka, K., Tanaka, M., Tsutsui, H., Kupper, T. S., Asahi, K., Okamura, H., Nakanishi, K., Suzuki, M., Kayagaki, N., Black, R.A., Miller, D.K., Nakashima, K., Shimizu, M. and Mizutani, H.
Skin-specific caspase-1 transgenic mice show cutaneous apoptosis and pre-shock condition with a high serum level of IL-18.
J. Immunol. 165:997-1003, 2000.
Fujimori, Y., Takatsuka, H., Takemoto, Y., Hara, H., Okamura, H., Nakanishi, K., Kakishita, E.
Elevated interleukin (IL)-18 levels during acute graft-versus-host disease after allogeneic bone marrow transplantation.
Br. J. Haematol., 109:652-657, 2000.
Chang, J. T., Segal, B.M., Nakanishi, K., Okamura, H. and Shevach, E.M.
The costimulatory effect of IL-18 on the induction of antigen-specific IFN-γ production by resting T cells is IL-12 dependent and is mediated by up-regulation of the IL- 12 recepter β2 subunit.
Eur. J. Immunol., 30:1113-1119, 2000.
Ohkusu, K., Yoshimoto, T., Takeda, K., Ogura, T., Kashiwamura, S-I., Iwakura, Y., Akira, S., Okamura, H. and Nakanishi, K.
Potentiality of Interleukin-18 as a useful reagent for the treatment and prevention of Leishmania major infection.
Infect. Immun., 68:2449-2456, 2000.
Nomura, F., Akashi, S., Sakao, Y., Sata, S., Kawai, T., Matsumoto, M., Nakanishi, K., Miyake, K., Kimoto, M., Takeda,K. and Akira, S.
Endotoxin tolerance in mouse peritoneal macrophages correlates with downregulation of surface TLR4 expression.
J. Immunol.,164:3476-3479, 2000.
Nomura, F., Kawai, T., Nakanishi, K. and Akira,S.
NFkB activation through IKK-i-dependent I-TRAF/TANK phosphorylation.
Genes Cells, 5:191- 202, 2000.
Tominaga, K., Yoshimoto, T., Torigoe, K., Kurimioto, M., Matsui, K., Okamura, H., Hada, T. and Nakanishi, K.
IL-12 synergizes with IL-18 or IL-1β for IFN-γ production from human T cells.
Int. Immunol., 12:151-160, 2000.
Kodama, T., Matsuyama, T., Kuribayashi, K., Nishioka, Y., Sugita, M., Akira, S., Nakanishi, K. and Okamura, H.
(1999) Interleukin-18 deficiency selectively enhances allergen-induced eosinophilia in mice.
J. Allergy Clinical Immunol., 105:45-53, 2000.
Okamura, H., Tsutsui, H., Kashiwamura, S-I., Yoshimoto, T. and Nakanishi, K.
IL-18 receptor.
In: The Cytokine Reference, (Oppenheim, J.J., Feldmann, M., Duram, S., Hirano, T., Vilcek, J. and Nicola, N.A. eds.), Academic Press, London, 1605-1609. 2000.
Okamura, H., Tsutsui, H., Kashiwamura, S-I., Yoshimoto, T. and Nakanishi, K.
Interleukin 18.
In: The Cytokine Reference, (Oppenheim, J.J., Feldmann, M., Duram, S., Hirano, T., Vilcek, J. and Nicola, N.A. eds.), Academic Press, London, 337-350. 2000.
Tsutsui, H., Matsui, K., Okamura, H. and Nakanishi, K.
Pathophysiological roles of interleukin-18 in inflammatory liver diseases.
Immunol. Rev., 174:192-209. 2000.
Tsutsui, H., Okamura, H. and Nakanishi, K.
Role of interleukin-18 for liver injury. Recent Res.
Devel. Immunol., 1:253-265. 2000.
