論文（1999年以前）
1999年
Hayashi, N., Matsui, K., Tsutsui, H., Osada, Y., Mohamed, R. T., Nakano, H., Kashiwamura, S-I., Hyodo, Y., Takeda, K., Akira, S., Hada, T., Higashino, K., Kojima, S. and Nakanishi, K.
Kupffer cells from Schistosoma mansoni-infected mice participate in the prompt type 2-differentiation of hepatic T cells in response to worm antigens.
J. Immunol. 163:6702-6711, 1999.
Hoshino, K., Kashiwamura, S-I., Kuribayashi, K., Kodama, T., Tsujimura, T., Nakanishi, K. Matsuyama, T., Takeda, K. and Akira, S.
The absence of Interleukin 1 receptor-related T1/ST2 does not affect T helper cell type 2 development and its effector function.
J. Exp. Med. 190:1541-1548, 1999.
Kaisho, T., Tsutsui, H., Tanaka, T., Tsujimura, T., Takeda, K., Kawai, T., Yoshida, N., Nakanishi, K. and Akira, S.
Impairment of natural killer cytotoxic activity and interferon-γ production in C/EBPg-deficient mice.
J. Exp. Med., 190:1573-1581, 1999.
Yoshimoto, T., Tsutsui, H., Tominaga, K., Hoshino, K., Okamura, H., Akira, S., William, E. Paul. and Nakanishi, K.
IL-18, although antiallergic when administered with IL-12, stimulates IL-4 and histamine release by basophils.
Proc. Natl. Acad. Sci. USA. 96: 13962-13966, 1999.
Tsutsui, H., Kayagaki, N., Kuida, K., Nakano, H., Hayashi, N., Takeda, K., Matsui, K., Kashiwamura, S-I., Hada, T., Akira, S., Yagita, H., Okamura, H. and Nakanishi, K.
Caspase-1-independetnt, Fas/Fas ligand-mediated IL-18 secretion from macrophages causes acute liver injury in mice.
Immunity., 11:359-367, 1999.
Yamamoto, T., Moriwaki, Y., Matsui, K., Takahashi, S., Tsutsui, H., Yoshimoto, T., Okamura, H., Nakanishi, K., Kurosawa, Y., Yamaguchi, S., Sasaki,Y. and Higashino, K.
IL-18 (interferon-γ-inducing factor) level in a purine nucleoside phosphorylase deficient patient.
Archives Dis Childhood, 81:179-180, 1999.
Kayagaki, N., Yamaguchi, N., Nakayama, M., Takeda, K., Akiba, H., Tsutsui, H., Okamuara, H., Nakanishi, K., Okumura, K. and Yagita, H.
Expression and function of TNF-related apoptosis-inducing ligand (TRAIL) on murine activated NK cells.
J. Immunol. 163: 1906-1913, 1999.
Hoshino, K., Tsutsui, H., Kawai, T., Takeda, K., Nakanishi, K., Takeda, Y. and Akira, S.
Generation of IL-18 receptor-deficient mice: Evidence for IL-1 receptor-related protein as an essential IL-18 binding receptor.
J. Immunol., 162:5041-5044, 1999.
Ueki, T., Kaneda, Y., Tsutsui, H., Nakanishi, K., Sawa, Y., Morishita, R., Matsumoto, K., Nakamura, T., Takahashi, H., Okamoto, E. and Fujimoto, J.
Hepatocyte growth factor gene therapy of liver cirrhosis in rats.
Nature Medicine, 5:226-230, 1999.
Sakao, Y., Takeda, K., Tsutsui, H., Kaisho, T., Nomura, F.,Okamura, H., Nakanishi, K. and Akira, S.
IL-18-deficiants mice resistant to endotoxin-inducedliver injury but highly susceptible to endotoxin shock.
Int. Immunol., 11: 471-480, 1999.
Hyodo, Y., Matsui, K., Hayashi, N., Tsutsui, H., Kashiwamura, S-I., Yamauchi, H., Hiroishi, K., Takeda, K., Tagawa, Y., Iwakura, Y., Kayagaki, N., Kurimoto, M., Okamura, H., Hada, T., Yagita, H., Akira, S., Nakanishi, K. and Higashino, K.
Interleukin 18 upregulates perforin-mediated NK activity without increasing perforin messenger RNA expression by binding to constitutively expressed IL-18 receptor.
J. Immunol. 162:1662-1668, 1999.
Tsuji, H., Mukaida, N., Harada,A., Kaneko, S., Matsushita, E.,Nakanuma, Y., Tsutsui, H., Okamura, H., Nakanishi, K., Tagawa, Y., Iwakura, Y.,Kobayashi, K. and Matsushima, K.
Alleviation of lipopolysaccharide-induced acute liver injury in Propionibacterium acnes—primed IFN-γ—deficient mice by a concomitant reduction TNF-α, IL-12, and IL-18 production.
J. Immunol., 162:1049-1055, 1999.
1998年
Yoshimoto, T., Takeda, K., Tanaka, T., Ohkusu, K., Kashiwamura, S-I., Okamura, H., Akira, S. and Nakanishi, K.
IL-12 upregulates IL-18R expression on T cells, Th1 cells and B cells: synergism with IL-18 for IFN-γ production.
J. Immunol., 161:3400-3407, 1998.
Yoshimoto, T., Nagai, N., Ohkusu, K., Ueda, H., Okamura, H. and Nakanishi, K.
LPS— stimulated SJL macrophages produce IL-12 and IL-18 that inhibit IgE production in vitro by induction of IFN-γ production from CD3intIL-2Rβ+ T cells.
J. Immunol., 161:1483-1492, 1998.
Adachi, O., Kawai, T., Takeda, K., Matsumoto, M., Tsutsui, H., Sakagami, M., Nakanishi, K. and Akira, S.
Targeted disruption of the MyD88 gene results in loss of IL-1-and IL-18-mediated function.
Immunity, 9:143-150, 1998.
Tomura, M., Zhou, X., Maruo, S., Ahn, H., Hamaoka, T., Okamura, H., Nakanishi, K., Tanimoto, T., Kurimoto, M. and Fujiwara, H.
A critical role for interleukin-18 in the proliferation and activation of NK1.1+CD3- cells
J. Immunol., 160:4738-4746, 1998.
Tomura, M., Maruo, S., Mu, J., Zhou, X., Ahn, H., Hamaoka, T., Okamura, H., Nakanishi, K., Clark, S., Kurimoto, M. and Fujiwara, H.
Diffential capacities of CD4+, CD8+ and CD4-, CD8- T cell subsets to express IL-18 receptor and produce IFN-γ in response to IL-18.
J. Immunol., 160: 3759-3765, 1998.
Takeda, K., Tsutsui, H., Yoshimoto, T., Adachi, O., Yoshida, N., Kishimoto, T., Okamura, H., Nakanishi, K. and Akira, S.
Defective NK cell activity and Th1 response in IL-18- deficient mice.
Immunity, 8:383-390, 1998.
Nakanishi, K., Ohkusu, K., Okamura, H. and Yoshimoto, T.
Molecular Mechanism of host resistance induced by IL-12 and IL-18 against infection with Leishmania major.
International parasitology. (Tada, I., Kojima, S. and Tsuji, M. eds.) 9:269-273. 1998.
Okamura, H., Tsutsui, H., Kashiwamura, S-I., Yoshimoto, T. and Nakanishi, K.
Interleukin-18 (IL-18) : a novel cytokine that augments both innate and acquired immunity.
Adv. Immunol., 70:281-312. 1998.
Okamura, H., Kashiwamura, S-I., Tsutsui, H., Yoshimoto, T. and Nakanishi, K.
Regulation of interferon-gamma (IFN-γ) production by IL-12 and IL-18. Curr. Opin.
Immunol., 10:259-264. 1998.
1997年
Tsutsui, H., Matsui, K., Kawada, N., Hyodo, Y., Hayashi, N., Okamura, H., Higashino, K. and Nakanishi, K.
IL-18 accounts for both TNF-α-and Fas Ligand-mediated hepatotoxic pathways in endotoxin-induced liver injury in mice.
J. Immunol., 159:3961-3967, 1997.
Ahn, H., Maruo, S., Tomura, M., Mu, J., Hamaoka, T., Nakanishi, K., Clark, S., Kurimoto, M., Okamura, H. and Fujuwara, H.
A mechanism underlying synergy between IL-12 and IFN-γ-inducing factor (IL-18) in enhanced production of IFN-γ.
J. Immunol., 159:2125- 2131, 1997.
Matsui, K., Yoshimoto, T., Tsutsui, T., Hyodo, Y., Hayashi, N., Hiroishi, K., Kawada, N., Okamura, H., Nakanishi, K. and Higashino, K.
Propionibacterium acnes treatment diminishes CD4+NK1.1+ T cells but induces Type 1 T cells in the liver by induction of IL-12 and IL-18.
J. Immunol., 159:97-106, 1997.
Yoshimoto, T., Okamura , H., Tagawa, Y., Iwakura , Y. and Nakanishi, K.
Interleukin-18 (IL-18) together with IL-12 inhibits IgE production by induction of IFN-γ production from activated B cells.
Proc. Natl. Acad. Sci. USA., 94:3948-3953, 1997.
Gu, Y., Kuida, K., Tsutsui, H., Ku G., Hsiao, K., Fleming, M. A., Hayashi, N., Higashino,K., Okamura, H., Nakanishi , K., et al.
Activation of Interferon-γ inducing factor mediated by Interferon-1b converting enzyme.
Science, 275:206-209, 1997.
Tsutsui, H., Nakanishi,K., Matsui, K., Higashino, K., Okamura, H., Miyazawa, Y. and Kaneda, K.
IL-18 upregulates Fas Ligand-mediated cytotoxic activity of murine NK cell clones.
Cells of the hepatic sinusoid. (Wisse, E., Knock, D.L. and Balabaud, C. eds.), Vol.6, The Kupffer cell foundation, The Netherlands. 337-339. 1997.
1996年
Saeki, N., Komatsu, T., Sakamoto, I., Funato, T. and Nakanishi, K.
The role of an FBS component in the trypanocidal reaction mediated by guinea pig serum. Jpn.
J. Parasitol, 45:474-480, 1996.
Tsutsui, H., Nakanishi, K., Matsui, K., Higashino, K., Okamura, H., Miyazawa, Y. and Kaneda, K.
Interferon g-inducing factor (IL-18) upregulates Fas ligand-mediated cytotoxic activity of murine natural killer cell clones.
J. Immunol., 157:3967-3973, 1996.
Saeki, N., Komatsu, T., Sakamoto, I., Funato, T. and Nakanishi, K.
Trypanocidal activity of guinea pig serum and BSA in the presence of an FBS component or cysteine. Jpn.
J. Parasitol, 45:280-289, 1996.
Takeda, K., Tanaka, T., Shi, W., Matsumoto, M., Minami, M., Kasiwamura, S., Nakanishi, K., Yoshida, N., Kishimoto, T. and Akira, S.
Essential role of STAT6 in IL-4 signaling.
Nature, 380:627-630, 1996.
Nakanishi, K., Matsui, K., Kashiwamura, S-I., Nishioka, Y., Nomura, J., Nishimura, Y., Sakaguchi, N., Yonehara, S., Higashino, K. and Shinka, S.
IL-4 and anti-CD40 protect against Fas-mediated B cell apoptosis and induce B cell growth and differentration.
Int.Immunol., 8:791-798, 1996.
1995年
Okamura H., Tsutsui H., Komatsu.T., Tanimoto, T., Nukata, Y., Tanabe, F., Akita, K., Torigoe, K., Okura, T., Fukuda, S. and Kurimoto, M.
Cloning of a new cytokine that induces IFN-γ production by T cells.
Nature. 378:88-91.,1995.
Ishizashi, H., Yoshimoto, T., Nakanishi, K., Tsujita, J. and Hori, S.
Effect of exercise on endotoxin shock with special reference to changes in concentration of cytokines. Jpn.
J. Physiol., 45,553-560, 1995.
Yoshimoto,T. Bendelac, A., Watson, C., Hu-Li, J. and Paul,W.E.
Role of NK1.1+ T cells in a Th2 response and in IgE production.
Science. 270:1845-1847.1995.
Yoshimoto,T. Bendelac, A., Hu-Li, J. and Paul,W.E.
Defective IgE production by SJL mice is linked to the absence of CD4+, NK1.1+ T cells that promptly produce IL-4.
Proc.Natl.Acad. Sci.USA.，92:11931-11934. 1995.
Nomura, J., Yamasaki, T., Kataoka, S., Maeda, K., Nakanishi, K. and Sakaguchi, N.
Anti-CD40 monoclonal antibody induces the proliferation of murine B cells as a B cell mitogen through a distinct pathway from receptors for antigens or lipopolysaccharide.
Immunol. Let., 45:195-203, 1995.
Tokuyama, H., Tokuyama, Y., and Nakanishi, K.
Retinoids inhibit IL-4-dependent IgE and IgG1 production by LPS-stimulated murine splenic B cells. Cell.
Immunol., 162:153-158, 1995.
Nakanishi, K., Yoshimoto, T., Chu, C., Matsumoto, H., Hase, K., Nagai, N., Tanaka, T., Miyasaka, M., Paul, W. E. and Shinka, S.
IL-2 inhibits IL-4-dependent IgE and IgG1 production in vitro and in vivo.
Int. Immunol., 7:259-268, 1995.
1994年
Yoshimoto, T. and Paul, W.E.
CD4POS, NK1. 1POS T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3.
J. Exp. Med, 179:1285-1295,1994.
Hirose, S., Nakanishi, K., Yoshimoto, T., Kashiwamura, SI., Hiroishi, K., Matsumoto, H., Hamaoka, T., Shinka, S. and Higashino, K.
Identification and characterization of IL-2 hyper-responsive NZB/WF1 CD5- B cells.
J. Immunol., 153:1847-1857, 1994.
