Sleep quality, metabolism, cognitive function, autonomic nervous system

Research related to lifestyle-related diseases and cardiovascular risk factors

The Hyogo Sleep Cardio-Autonomic Atherosclerosis (HSCAA) cohort study, which aims to objectively and comprehensively evaluate daily sleep, fatigue, daytime activity, and autonomic nervous function, track the pathology and prognosis of endocrine and metabolic diseases, and clarify the significance of biological stress such as sleep, fatigue, and autonomic nervous dysfunction, has been conducted since 2010. As of the end of 2022, approximately 1,200 patients have been enrolled and have been followed up for an average of 3.6 years.
Recently, a series of reports have shown that a decline in sleep quality is associated with decreased insulin secretion and sensitivity (Kakutani-Hatayama M, et al. Metabolism Open 2020, 6:100033), a correlation between autonomic nervous function and indicators of left ventricular diastolic function (Morimoto A, et al.Metabolism Open 2020, 5: 100025), and the risk of decreased sleep quality and autonomic nervous dysfunction worsening renal function in diabetic patients without renal dysfunction (Kadoya M et al. Sci Rep2021, 11: 19048).

It objectively and comprehensively evaluates daily sleep, fatigue, daytime activity, and autonomic nervous function, and clarifies the correlation with the pathology and prognosis of endocrine and metabolic diseases.

The study contains enrollment and follow-up data from a large number of participants (approximately 1,200 patients), making it possible to perform a variety of analyses.

• Data from active tracer (24-hour, autonomic nervous function assessment) and actigraph (sleep assessment) at the time of enrollment
• Long-term follow-up data (average 3.6 years)

Early prediction or detection of cardiovascular events is an important issue for diabetic patients.
Analysis of the data obtained from this cohort study may lead to the discovery of new biomarkers for predicting cardiovascular disorders.

There is potential for new product development based on approaches such as sleep and stress.
As we enter the COVID-19 era, the importance of the "quality" of sleep in particular is becoming more and more recognized due to changes in living environments brought about by digitalization, and this perspective may be able to support the development of products to maintain future health.

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1. Kadoya Manabu, et al.Sleep quality, autonomic dysfunction and renal function in diabetic patients with pre-CKD phase.Scientific Reports 2021;11:19048
2. Kakutani-Hatayama M, et al. Metabolism Open 2020, 6:100033