Research Seeds Collection

Development of gene and cell therapy for intractable cancers and hereditary diseases

Cancer virus therapy, gene and cell therapy

Analysis of the mechanism of action of immune activators

Adjuvants, innate immunity, adaptive immunity

Creation of a one-lung interstitial pneumonia model

Interstitial pneumonia, mouse, bleomycin, one lung

Research into biological stress responses caused by lifestyle factors such as sleep, fatigue, and autonomic nervous function (Hyogo Sleep Cardio-Autonomic Atherosclerosis Study: HSCAA Study)

Sleep quality, metabolism, cognitive function, autonomic nervous system

Analysis of pathophysiological functions of RAGE using genetically engineered models and adenovirus expression

Chronic subclinical inflammation, cognitive function, RAGE

A multicenter collaborative study on the relationship between blood glucose fluctuations, including hypoglycemia, and diabetic complications in diabetic patients (Hyogo Diabetes Hypoglycemia Cognition Complications study: HDHCC study)

Sleep quality, metabolism, cognitive function, autonomic nervous system

Cohort study of elderly people living in the Tamba-Sasayama area: FESTA (Frail Elderly in the Tamba-Sasayama Area) study

Frailty, sarcopenia, cognitive impairment, osteoporosis, lifestyle habits (diet, physical activity, sleep, social activity), biomarkers, QOL

Development of new treatment strategies combining cancer IVR and immunotherapy

IVR Radiofrequency coagulation therapy, cryotherapy, arterial embolization, portal vein embolization, immunotherapy, immune checkpoint, hypoxic response, hypoxia-inducible factor, drug delivery

Development of a social prescription support app for patients with chronic cardiovascular disease using CBR matrix

CBR matrix, social prescribing, app development

Development of novel heart failure drugs targeting organ-specific kinase (cardiac-specific myosin regulatory light chain kinase)

Dilated cardiomyopathy, cMLCK, heart failure drug, MLC2v

Development of organ-specific cancer drugs using drug repositioning

Tumor-associated macrophages, itraconazole

Development of a novel neural regeneration therapy targeting endogenous stem cells specifically induced during cerebral infarction pathology

Stem cells, cerebral infarction, neural regeneration, traumatic brain disease, regenerative medicine

Breathing control improves task performance and reduces stress

Breathing, cognitive function, stress reduction, autonomic nervous system

Searching for therapeutic targets for lifestyle-related diseases through regulation of aging-associated immune mechanisms

Aging, immunity, lifestyle-related diseases

Search for biomarkers related to invasion and metastasis via partial-EMT in oral cancer

Oral squamous cell carcinoma, tumor budding, biomarker

MicroRNA derived from exosomes in the blood of cancer patients

exosome, microRNA, cancer, Molecular Biology

Development of a general anesthesia index (NR) to reduce the risk of postoperative complications

Surgical stress, nociception

Identification of sentinel lymph nodes in gallbladder cancer by fluorescence imaging and elucidation of their clinical significance

Fluorescence imaging, sentinel lymph node

Elucidation of the involvement of immune cells in the establishment and maintenance of pregnancy and development of new treatments

Immunocompetent cells, NK cells, cytokines, infertility, miscarriage

The role of Reg family proteins in gut microbiota disturbance and gastrointestinal microinflammation

Regenerating gene (Reg) protein

Evaluating the efficacy of drugs against pain and pruritus and elucidating the neurophysiological mechanisms of analgesia and anti-itch

Pain, in vivo patch clamp, drug efficacy evaluation, emotion evaluation, itch

Research into the reality of gluten intolerance and mental health

Schizophrenia, depression, gluten, gluten-free diet, immunity

Development of a novel vascular regeneration therapy using angiogenesis-inducing cells (AiC) derived from umbilical cord blood and peripheral blood

Vascular regeneration, umbilical cord blood, peripheral blood

Development of an artificial ovary using decellularized human ovarian tissue

Cancer reproduction, ovarian freezing, decellularization, artificial ovary

Pressure-clamp Analysis of physiological functions of various cells using patch clamp technique

Ion channels, Physiology, Department of Pharmacology

Target Discovery Using Affinity Resins

Target Discovery, Affinity Resins, AquaFirmus

Synthetic intermediates for producing 3-haloaranes and aromatic compound library utilizing the reactions

Aryne, benzyne, halogen, aromatic ring, polycyclic heterocycle

Development of interactive self-learning materials using digital technology

Natural language processing, IcT, VR, AR, simulation education

Prenatal education program to enable independent decision-making regarding prenatal Department of Genetics testing (NIPT)

Prenatal testing, decision making, and preconception education

A study on sex education in the home for early childhood

Sex education, parental sex education, positive sex education

Establishment and evaluation of a multidisciplinary collaborative practice method to support the unique life stages brought about by rheumatoid arthritis

Rheumatoid arthritis, multidisciplinary collaboration, rehabilitation, preconception

Development of a basic education model for midwives on palliative care for labour pain in Morocco

Pain relief for childbirth, midwife, Morocco, basic midwife education, international nursing, international cooperation

Research on support for pregnant women and parturient women who are HTLV-1 positive

HTLV-1 positive, pregnant women, feeding method, short-term breastfeeding, decision-making

Research and activities related to disaster preparedness for mothers and children

Disaster, women, mothers and children, families, preparedness

Research on disaster preparedness for foreigners in Japan

Disaster, foreigners, preparation, nursing, accommodation, community

The status and measures of constipation in elderly people with severe care needs

Electroenterogram, peristalsis, ultrasound examination

A study on preconception care by nurses for patients with chronic diseases

Preconception care, chronic illness, nurses

Development of a community-based practical social life management program for people with acquired brain injury

Acquired brain injury, higher brain dysfunction, social life, community rehabilitation

The effect of patient education incorporating pain rhythm on daily living activities and quality of life in patients with chronic pain

Pain rhythm, physical activity level, patient education

An animal model in which genetic and environmental interactions induce depression

Depression, psychiatric disorders, animal models, mice, genetic-environmental interactions, epigenetics, behavioral experiments, behavioral science

Development of a rehabilitation system for frail elderly people by supporting their physical activity

Frailty and physical activity