兵庫医科大学皮膚科学教室

電話0798-45-6240
受付8:30〜11:00 電話予約15:00〜16:30
http://www.hyo-med.ac.jp/department/drmt/

 
 

当講座は阪神地区の皮膚科診療の中核としての活動を行うとともに、一方では我が国における皮膚科学の研究・教育拠点としての一翼を担っています。皮膚科学を通じて様々な形で皆様のお役に立てるように、講座関係者一同、誠心誠意努力しております。また、皮膚科専門医の研修機関として、皮膚病理組織、皮膚免疫・アレルギー疾患、皮膚感染症、皮膚外科など、幅広い経験を通じて十分な臨床能力を備えた皮膚科専門医の育成を目指しています。皮膚科学研究については、形態、免疫、遺伝子からプロテオミクスまで、共同利用施設の充実と専門スタッフの支援により研究しやすい体制が整っています。アメニティー豊かで全国有数の生活環境に恵まれた阪神間で、皮膚科医としての修練や先進的な皮膚科学研究を希望される方は、出身大学にかかわらず、ご遠慮無くご相談下さい。見学随時、入局、皮膚科研修、大学院希望者は秘書までご連絡ください。個別に対応いたします。(医師入局連絡先:TEL 0798-45-6653)


略歴>


昭和56年 京都府立医科大学卒
昭和60年 京都府立医科大学大学院修了、医学博士
昭和60年 福井医科大学皮膚科学講座文部教官助手
昭和61年 大阪大学細胞工学センター遺伝子情報研究部門研究生
昭和62年 京都府立医科大学皮膚科学教室助手 
平成 3年 京都府立医科大学皮膚科学教室講師
平成14年 三重大学医学部皮膚科学講座文部科学教官助教授

 

現在の研究テーマ:皮膚疾患の分子病態解析と、それに基づく新しい診断・治療法の開発

私たちが診療いたします

講座医局員一覧 令和2年10月現在 

 主任教授      金澤伸雄
 
 准教授       夏秋 優
 
 講師        伊藤孝明
 
 講師        
 医局長       今井康友
 外来医長
 
 病棟医長
 助教        永井 諒

 助教        井上裕香子

 助教           和田吉弘 

 病院助手      富永千春

 医師(大学院)   草壁みのり

 特別招聘教授    山西清文 (えいご皮膚科)

 非常勤医師     谷口怜子

 非常勤医師        羽田孝司 (羽田皮膚科)
 非常勤講師

 医師(大学院)   松谷雅子

 レジデント(大学院) 尼木麻実 

 レジデント     林 秀樹

 レジデント     藤本真由 
 レジデント(大学院) 北佳奈子

 レジデント(大学院) 宮本翔子(市立伊丹病院)

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(教育関係・協力施設等)


 臨床教育教授    黒川一郎
 明和病院皮膚科    
       
 臨床教育教授    南祥一郎
 市立伊丹病院部長

 特別招聘教授
 医療法人正英会
 えいご皮膚科    山西清文
 武庫川院院長

 --------------
(事務員)

 実験補助・ラボ   坂口祥子
 
 実験補助・ラボ   今田淳子

 実験補助・事務   平井絵美 

 実験補助・事務   助野智子

 実験補助・事務   宮村麻子

 医療事務作業補助  伊藤真里子

<主な研究業績:山西清文>


Tominaga C, Yamamoto M, Ima Y, Yamanishi K. A case of old age-onset generalized pustular psoriasis with a deficiency of IL-36RN (DITRA) treated by granulocyte and monocyte apheresis. Case Reports in Dermatology (in press)

Suga Y, Tsuda T, Nagai M, Sakaguchi Y, Jitsukawa O,Yamamoto M, Hitomi K, Yamanishi K. Lamellar ichthyosis with pseudoexon activation in the transglutaminase 1 gene. J Dermatol (in press)

Inoue Y, Yamamoto M, Sakaguchi Y, Jitsukawa O, Hayano K, Yamane M, Sakamoto M, Yamanishi K. ABCA12-deficient Congenital ichthyosiform erythroderma in a boy with an intellectual developmental delay. Acta Derm Venereol (in press)

Nagai M, Nagai H, Tominaga C, Sakaguchi Y, Jitsukawa O, Ohgo N, Nishigori C, Yamanishi K. Localised dominant dystrophic epidermolysis bullosa with a novel de novo mutation in COL7A1 diagnosed by next-generation sequencing. Acta Derm Venereol (in press)

Kawasaki K, Yamanishi K, Yamada H.Age-related morphometric changes of inner structures of the skin assessed by in vivo reflectance confocal microscopy.Int J. Dermatol (in press)

Washio K, Fukunaga A, Terai M, Hitomi K, Yamanishi K, Nishigori C. Hypohidrosis plays a crucial role in the vicious circle of bathing suit ichthyosis: a case with summer exacerbation. Acta Derm Venereol 94:349-350, 2014

Imai Y, Yasuda K, Sakaguchi Y, Futatsugi-Yumikura S, Yoshimoto T, Nakanishi K, Yamanishi K. Immediate-type contact hypersensitivity is reduced in interleukin-33 knockout mice. J Dermatol Sci 74:159-161, 2014

Yoshimi N, Imai Y, Kakuno A, Tsubura A, Yamanishi K. Epithelial keratin and filaggrin expression in seborrhoeic keratosis -Evaluation based on histopathological classification.Int J. Dermatol 53:707-713, 2014


<ガルデルマ賞受賞>

Imai Y, Yasuda K, Sakaguchi Y, Haneda T, Mizutani H, Yoshimoto T, Nakanishi K, Yamanishi K.Skin-specific expression of IL-33 activates group 2 innate lymphoid cells and elicits atopic dermatitis-like inflammation in mice.Proc Natl Acad Sci USA 110:13921-6, 2013


Itoh M, Tatsukawa H, Eun-Seo L,Yamanishi K, Kojima S, Hitomi K.Variations in Both TG1 and TG2 isozyme-specific in situ activities and protein expressions during mouse embryonic development. J Histochem Cytochem. 61:793-801, 2013

Yamamoto M, Imai Y, Sakaguchi Y, Haneda T, Yamanishi K. Serum cytokines correlated with the disease severity of generalized pustular psoriasis. Dis Markers 34:153-161, 2013

Otani N, Yamanishi K, Sakaguchi Y, Imai Y, Shima M, Okuno T. Varicella-zoster virus-specific cell-mediated immunity in subjects with herpes zoster. J Immunol Methods 30:53-55,2012

Nakagawa N,Yamamoto M, Imai Y, Sakaguchi Y, Takizawa T, Noboru O,Yagi N,Hatta I, Hitomi K, Takizawa T, Tsuda T, Matsuki M, Takeda J, Yamanishi K. Knocking-in the R142C mutation in transglutaminase 1 disrupts the stratum corneum barrier and postnatal survival of mice. J Dermatol Sci 65:196-206,2012

Yamamoto M, Sakaguchi Y, Itoh M, Nakagawa N, Fukunaga A, Hitomi K, Yamanishi K. Bathing suit ichthyosis with summer exacerbation: A temperature-sensitive case.Br J Dermatol 166:672-674,2012

Imai Y, Tsuda T, Aochi S, Yumikura S, Sakaguchi Y, Nakagawa N, Iwatsuki K, Yamanishi K. YKL-40 (Chitinase 3-Like-1) as a biomarker for psoriasis vulgaris and pustular psoriasis.J Dermatol Sci 64:75-77,2011

Aochi S, Tsuji K, Sakaguchi M, Huh N, Tsuda T, Yamanishi K, Komine M, Iwatsuki K. Markedly elevated serum levels of calcium-binding S100A8/A9 proteins in psoriatic arthritis are due to activated monocytes/macrophages J Am Acad Dermatol 64:879-887,2011

Itoh M, Kawamoto T, Tatsukawa H, Kojima S, Yamanishi K, Hitomi K.In Situ Detection of Active Transglutaminases for Keratinocyte-type (TGase 1) and Tissue-type (TGase 2) Using Fluorescence-labeled Highly Reactive Substrate Peptides. J Histochem Cytochem. 59:180-187,2011

Omoto Y, Yamanaka K, Tokime K, Kitano S, Kakeda M, Akeda T, Kurokawa I, Gabazza EC, Tsutsui H, Katayama N, Yamanishi K, Nakanishi K, Mizutani H. Granzyme B is a novel interleukin-18 converting enzyme J Dermatol Sci.59: 129-35, 2010

Tarutani M, Imai Y, Yasuda K, Tsutsui H, Nakanishi K, Yamanishi K. Neutrophil-dominant psoriasis-like skin inflammation induced by epidermal-specific expression of Raf in mice. J Dermatol Sci. 58:28-35, 2010

Ishikawa C, Tsuda T, Konishi H, Nakagawa N, Yamanishi K. Tetracyclines modulate protease-activated receptor 2-mediated proinflammatory reactions in epidermal keratinocytes. Antimicrob Agents Chemother, 53:1760-1765,2009

Fujimoto T, Tsuda T, Yamamoto M, Tarutani M, Natsuaki M, Minami S, Ito T, Kozuka T, Yamanishi K. Cutaneous malignant fibrous histiocytoma (undifferentiated pleomorphic sarcoma) arising in a chronic scalp ulcer of a patient with non-bullous congenital ichthyosiform erythroderma. J Eur Acad Dermatol Venereol, 23:202-203, 2009

Tsujimura A, Matsuki M, Takao K, Yamanishi K, Miyakawa T, Hashimoto-Gotoh T. Mice lacking the kf-1 gene exhibit increased anxiety- but not despair-like behavior. Frontiers Behavioral Neurosci, 2:1-11, 2008

Sugimura Y, Hosono M, Kitamura M, Tsuda T, Yamanishi K, Maki M, Hitomi K. Identification of preferred substrate sequences for transglutaminase 1-development of a novel peptide that can efficiently detect cross-linking enzyme activity in the skin. FEBS J, 275:5667-5677,2008

Tsuda T, Ishikawa C, Nakagawa N, Konishi H, Tarutani M, Matsuki M, Yamanishi K. A novel point mutation of keratin 17 (KRT17) in a Japanese family with pachyonychia congenita type 2: An RNA-based genetic analysis using a single hair bulb. Br J Dermatol, 159:730-732,2008

Miyata A, Natsuaki M, Yamanishi K. Staphylococcal enterotoxin B enhances a flare-up reaction of murine contact hypersensitivity through up-regulation of interferon-gamma. Exp Dermatol, 17:843-848, 2008

Tsuda T, Ishikawa C, Konishi H, Hayashi Y, Nakagawa N, Matsuki M, Mizutani H, Yamanishi K. The effect of 14-membered ring macrolides on the production of interleukin-8 mediated by protease-activated receptor 2 in human keratinocytes. Antimicrob Agents Chemother, 52:1538-1541, 2008


<日本皮膚科学会皆見賞受賞>

Omoto Y, Tokime K,Yamanaka K, Habe K, Morioka T, Kurokawa I, Tsutsui H, Yamanishi K, Nakanishi, K, Mizutani H. Human mast cell chymase cleaves pro-IL-18 and generates a novel and biologically active IL-18 fragment. J Immunol, 177:8315-8319, 2006


Terada M, Tsutsui H, Yasutomo I, Yasuda K, Mizutani H, Yamanishi K, Kubo M, Matsui K, Sano H, Nakanishi K. Contribution of interleukin-18 to atopic dermatitis-like skin inflammation induced by Staphylococcus aureus product in mice. Proc Natl Acad Sci USA, 103:8816-8821, 2006

Matsuno K, Yamada H, Iwata K, Jin D, Katsuyama M, Matsuki M, Takai S, Yamanishi K, Miyazaki M,Hiroaki Matsubara, Yabe-Nishimura C. Nox1 Is Involved in Angiotensin II-mediated Hypertension - A Study in Nox1-deficient mice, Circulation 112: 2677-2685, 2005

Kuramoto N, Takizawa, T, Takizawa, T, Matsuki M, Morioka H, Robinson JM, Yamanishi K. Development of ichthyosiform skin compensates for defective permeability barrier function in mice lacking transglutaminase 1. J Clin Invest 109: 243-250, 2002

Shen CS, Tabata K, Matsuki M, Goto T, Yokochi T, Yamanishi K. Premature apoptosis of keratinocytes and the dysregulation of keratinization in porokeratosis. Br J Dermatol 147: 498-502, 2002

Sayama K, Hanakawa Y, Shirakata Y, Yamasaki K, Sawada Y, Sun L, Yamanishi K, Ichijo H, Hashimoto K. Apoptosis signal regulating kinase 1 (ASK1) is an intracellular inducer of keratinocyte differentiation. J Biol Chem 276: 999-1004, 2001

Inada R, Matsuki M, Yamada K, Morishima Y, Shen S-C, Kuramoto N, Yasuno H, Takahashi K, Miyachi Y, and Yamanishi K. Facilitated wound healing by activation of the transglutaminase 1 gene. Am J Pathol 157: 1875-1882, 2000

Hiiragi T,Sasaki H,Nagafuchi A,Sabe H,Shen SC,Matsuki M,Yamanishi K, Tsukita S. Transglutaminase type 1 and its cross-linking activity are concentrated at adherens junctions in simple epithelial cells. J Biol Chem 274:34148-34154, 1999

Nishida K,Yamanishi K,Yamada K,Dota A,Kawasaki S,Quantock AJ, Kinoshita S. Epithelial hyperproliferation and transglutaminase 1 gene expression in Stevens-Johnson syndrome conjunctiva. Am J Pathol 154:331-336, 1999


<日本皮膚科学会皆見賞受賞>

Matsuki M, Yamashita F, Ishida-Yamamoto A, Yamada K, Kinoshita C, Fushiki S, Ueda E, Morishima Y, Tabata K, Yasuno H, Hashida M, Iizuka H, Ikawa M, Okabe M, Kondoh G, Kinoshita T, Takeda J, Yamanishi K. Defective stratum corneum and early neonatal death in mice lacking the gene for transglutaminase 1 (keratinocyte transglutaminase). Proc Natl Acad Sci USA 95 :1044-1049, 1998


Takahashi K, Yan B, Yamanishi K, Imamura S, Coulombe PA. The two functional keratin 6 genes of mouse are differentially regulated and evolved independently from their human orthologs. Genomics 53:170-183, 1998

Kawabe S, Ikuta T, Ohba M, Chida K, Ueda E, Yamanishi K, Kuroki T. Cholesterol sulfate activates transcription of transglutaminase 1 gene in normal human keratinocytes. J Invest Dermatol 111 :1098-1102, 1998

Yamada K, Matsuki M, Morishima Y, Ueda E, Tabata K, Yasuno H, Suzuki M, Yamanishi K. Activation of the human transglutaminase 1 promoter in transgenic mice: Terminal differentiation-specific expression of theTGM1-lacZ transgene in keratinized stratified squamous epithelia. Hum Mol Genet 6 :2223-2231, 1997

Ueda E,Ohno S,Kuroki T,Livneh E,Yamada K,Yamanishi K, Yasuno H. The eta isoform of protein kinase C mediates transcriptional activation of the human transglutaminase 1 gene. J Biol Chem 271:9790-9794, 1996

Morishima Y,Ariyama T,Yamanishi K,Abe T,Ueda E,Yasuno H,  Inazawa J. Chromosomal loci of 50 human keratinocyte cDNAs assigned by fluorescence in situ hybridization. Genomics 28:273-279, 1995

Konishi K,Morishima Y,Ueda E,Kibe Y,Nonomura K,Yamanishi K, Yasuno H. Cataloging of the genes expressed in human keratinocytes: Analysis of  607 randomly isolated cDNA sequences. Biochem Biophys Res Commun 202:976-983, 1994

Yamanishi K,Matsuki M,Konishi K, Yasuno H. A novel mutation of Leu122 to Phe at a highly conserved hydrophobic residue in the helix initiation motif of keratin 14 in epidermolysis bullosa simplex. Hum Mol Genet 3:1171-1172,1994

Nonomura K, Yamanishi K, Yasuno H,Nara K, Hirose S. Up-regulation of elafin/SKALP gene expression in psoriatic epidermis. J Invest Dermatol 103:88-91, 1994

Nonomura K,Yamanishi K,Hosokawa Y,Doi H,Hirano J,Fukushima S, Yasuno H Localization of transglutaminase 1 mRNA in normal and psoriatic epidermis by non-radioactive in situ hybridization. Br J Dermatol 128:23-28, 1993

Yamanishi K,Inazawa J,Liew FM, Nonomura K,Ariyama T,Yasuno H,Abe T,Doi H,Hirano J, Fukushima S. Structure of the gene for human transglutaminase 1. J Biol Chem 267:17858-17863, 1992

Yamanishi K, Liew FM, Konishi K,Yasuno H,Doi H,Hirano J, Fukushima S. Molecular cloning of human epidermal transglutaminase cDNA from keratinocytes in culture. Biochem Biophys Res Commun 175:906-913,1991

Fujita T,Shibuya H,Ohashi T,Hotta H,Yamanishi K, Taniguchi T.  Interferon-β gene regulation: Tandemly repeated sequence of a synthetic 6 bp oligomer function as a virus-inducible enhancer.Cell 49:357-367, 1987

Fujita T,Shibuya H,Ohashi T, Yamanishi K, Taniguchi T. Regulation of human interleukin-2 gene:Functional DNA sequence in the 5' flanking region for the gene expression in activated T lymphocytes. Cell 46:401-407,1986

 
講座のVision
兵庫医科大学 皮膚科学
特別招聘教授
山西清文

本研究は、Yahoo!のトップ記事で紹介されました。国内特許出願済み、国際特許申請中です。私たちと一緒に研究してくれる医師・大学院生も募集中です。

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